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Rab34 RAB34, member RAS oncogene family [ Mus musculus (house mouse) ]

Gene ID: 19376, updated on 27-Nov-2024

Summary

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Official Symbol
Rab34provided by MGI
Official Full Name
RAB34, member RAS oncogene familyprovided by MGI
Primary source
MGI:MGI:104606
See related
Ensembl:ENSMUSG00000002059 AllianceGenome:MGI:104606
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rah; Narr; Rah1
Summary
Enables GTPase activity and guanyl nucleotide binding activity. Involved in several processes, including Golgi to plasma membrane protein transport; organelle assembly; and positive regulation of protein localization to phagocytic vesicle. Acts upstream of or within endocytosis. Located in Golgi apparatus; endosome; and ruffle. Colocalizes with phagocytic vesicle. Is expressed in several structures, including adrenal gland; alimentary system; brain; genitourinary system; and respiratory system. Human ortholog(s) of this gene implicated in orofaciodigital syndrome XX. Orthologous to human RAB34 (RAB34, member RAS oncogene family). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in adrenal adult (RPKM 68.8), ovary adult (RPKM 45.7) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Rab34 in Genome Data Viewer
Location:
11 B5; 11 46.74 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (78079253..78083019)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (78188427..78192193)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5250 Neighboring gene small nucleolar RNA, C/D box 4A Neighboring gene ribosomal protein L23A Neighboring gene small nucleolar RNA, C/D box 42B Neighboring gene Rab34 Hedgehog-responsive enhancer Neighboring gene protein interacting with cyclin A1 Neighboring gene SPT6, histone chaperone and transcription elongation factor Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:78029402-78029555

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Rab34 is necessary for early stages of intracellular ciliogenesis. Stuck MW, et al. Curr Biol, 2021 Jul 12. PMID 33989524, Free PMC Article
  2. Ciliary and non-ciliary functions of Rab34 during craniofacial bone development. Yamaguchi H, et al. Biochem Biophys Res Commun, 2024 Sep 10. PMID 38852507
  3. Molecular cloning of a member of a new class of low-molecular-weight GTP-binding proteins. Morimoto BH, et al. Genes Dev, 1991 Dec. PMID 1752434
  4. Spatial distribution of phagolysosomes is independent of the regulation of lysosome position by Rab34. Kasmapour B, et al. Int J Biochem Cell Biol, 2013 Sep. PMID 23871933
  5. Identification and characterization of a novel ubiquitous nucleolar protein 'NARR' encoded by a gene overlapping the rab34 oncogene. Zougman A, et al. Nucleic Acids Res, 2011 Sep 1. PMID 21586586, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rab34 GTPase mediates ciliary membrane formation in the intracellular ciliogenesis pathway.
    Title: Rab34 GTPase mediates ciliary membrane formation in the intracellular ciliogenesis pathway.
  2. Rab34 is necessary for early stages of intracellular ciliogenesis.
    Title: Rab34 is necessary for early stages of intracellular ciliogenesis.
  3. Authors demonstrate that endocytic recycling protein Rab34 localizes to cilia, and that its mutation results in significant decrease of ciliogenesis in both cultured cells and mice. Rab34 is required for the successive fusion of preciliary vesicles to generate ciliary vesicles and for the migration of the mother centriole from perinuclear region to plasma membrane.
    Title: Rab34 small GTPase is required for Hedgehog signaling and an early step of ciliary vesicle formation in mouse.
  4. CSN6 and Rab34 are involved in AR trafficking by regulating the phosphorylation signaling pathway. These findings provide new insights into the testosterone signaling pathway in Sertoli cells that mediates spermatogenesis.
    Title: CSN6 and Rab34 Are Involved in Androgen Receptor Trafficking in Mouse Testicular Sertoli Cells.
  5. Loss-of-function mutations in the Rab34 gene lead to defects in the assembly of primary cilia, in the trafficking of proteins to primary cilia and, consequently, to impaired reception of signals from the Hedgehog pathway.
    Title: CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog.
  6. Although Rab34 regulates both lysosomal positioning and lysosome to phagosome fusion, the latter effect is not due to the regulation of the cytoplasmic accessibility of lysosomes to phagosomes by Rab34.
    Title: Spatial distribution of phagolysosomes is independent of the regulation of lysosome position by Rab34.
  7. uncover Rab34/Munc13-2 as a critical part of an alternative Rab7-independent phagosome maturation machinery and lysosome-mediated killing of mycobacteria
    Title: Size-dependent mechanism of cargo sorting during lysosome-phagosome fusion is controlled by Rab34.
  8. association with membrane ruffles and macropinosomes and promotes macropinosome formation
    Title: Small GTPase Rah/Rab34 is associated with membrane ruffles and macropinosomes and promotes macropinosome formation.
  9. results have uncovered a novel mechanism for interorganellar trans-regulation of spatial distribution of lysosomes by Golgi-associated Rab34
    Title: Interorganellar regulation of lysosome positioning by the Golgi apparatus through Rab34 interaction with Rab-interacting lysosomal protein.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanyl nucleotide binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Golgi to plasma membrane protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Golgi to plasma membrane protein transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in Golgi to plasma membrane protein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in antigen processing and presentation ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cytosolic ciliogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lysosomal transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lysosome localization ISO
Inferred from Sequence Orthology
more info
  
involved_in phagosome maturation ISO
Inferred from Sequence Orthology
more info
  
involved_in phagosome maturation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phagosome-lysosome fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phagosome-lysosome fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phagosome-lysosome fusion ISO
Inferred from Sequence Orthology
more info
  
involved_in phagosome-lysosome fusion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of defense response to bacterium IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of protein localization to phagocytic vesicle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in Golgi cisterna IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi cisterna ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi stack ISO
Inferred from Sequence Orthology
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
located_in centriole ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in late endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with phagocytic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in phagocytic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in phagocytic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in phagocytic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in ruffle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ras-related protein Rab-34
Names
RAB34, member of RAS oncogene family
rab-39
ras-related homolog
ras-related protein Rab-39
ras-related protein Rah

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159482.1 → NP_001152954.1  ras-related protein Rab-34

    See identical proteins and their annotated locations for NP_001152954.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA041780, AB082927, AF327929, AV142766, BY317641
    Consensus CDS
    CCDS25094.1
    UniProtKB/Swiss-Prot
    Q64008, Q8BHJ0, Q99P59, Q99P90
    UniProtKB/TrEMBL
    Q0PD20
    Related
    ENSMUSP00000002128.8, ENSMUST00000002128.14
    Conserved Domains (2) summary
    smart00175
    Location:54 → 213
    RAB; Rab subfamily of small GTPases
    cd04108
    Location:53 → 220
    Rab36_Rab34; Rab GTPase families 34 (Rab34) and 36 (Rab36)

  2. NM_033475.3 → NP_258436.2  ras-related protein Rab-34

    See identical proteins and their annotated locations for NP_258436.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AB082927, AV142766, BB643883, BY195955, BY234941
    Consensus CDS
    CCDS25094.1
    UniProtKB/Swiss-Prot
    Q64008, Q8BHJ0, Q99P59, Q99P90
    UniProtKB/TrEMBL
    Q0PD20
    Related
    ENSMUSP00000103958.3, ENSMUST00000108322.9
    Conserved Domains (2) summary
    smart00175
    Location:54 → 213
    RAB; Rab subfamily of small GTPases
    cd04108
    Location:53 → 220
    Rab36_Rab34; Rab GTPase families 34 (Rab34) and 36 (Rab36)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    78079253..78083019
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q64008.2 GenPept UniProtKB/Swiss-Prot:Q64008

Gene LinkOut

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