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Zbtb12 zinc finger and BTB domain containing 12 [ Mus musculus (house mouse) ]

Gene ID: 193736, updated on 27-Nov-2024

Summary

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Official Symbol
Zbtb12provided by MGI
Official Full Name
zinc finger and BTB domain containing 12provided by MGI
Primary source
MGI:MGI:88133
See related
Ensembl:ENSMUSG00000049823 AllianceGenome:MGI:88133
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
G10; Bat9; NG35; Bat-9
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be active in nucleoplasm. Orthologous to human ZBTB12 (zinc finger and BTB domain containing 12). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E14 (RPKM 33.4), whole brain E14.5 (RPKM 32.0) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Zbtb12 in Genome Data Viewer
Location:
17 B1; 17 18.43 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35113514..35115820)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34894559..34896867)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene microRNA 6972 Neighboring gene complement factor B Neighboring gene complement C2 Neighboring gene STARR-seq mESC enhancer starr_42440 Neighboring gene predicted gene, 40706 Neighboring gene euchromatic histone lysine N-methyltransferase 2 Neighboring gene solute carrier family 44, member 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. P1 and cosmid clones define the organization of 280 kb of the mouse H-2 complex containing the Cps-1 and Hsp70 loci. Gasser DL, et al. Immunogenetics, 1994. PMID 7993390
  2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger and BTB domain-containing protein 12
Names
HLA-B-associated transcript 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410323.1 → NP_001397252.1  zinc finger and BTB domain-containing protein 12 isoform 1

    Status: VALIDATED

    Source sequence(s)
    CT025759
    UniProtKB/TrEMBL
    Q9Z150

  2. NM_001410324.1 → NP_001397253.1  zinc finger and BTB domain-containing protein 12 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CT025759

  3. NM_198886.4 → NP_942589.3  zinc finger and BTB domain-containing protein 12 isoform 1

    See identical proteins and their annotated locations for NP_942589.3

    Status: VALIDATED

    Source sequence(s)
    CT025759
    Consensus CDS
    CCDS28665.1
    UniProtKB/TrEMBL
    Q6P6L4, Q9Z150
    Related
    ENSMUSP00000057515.9, ENSMUST00000052778.10
    Conserved Domains (5) summary
    COG5048
    Location:361 → 448
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:361 → 381
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:359 → 381
    zf-C2H2; Zinc finger, C2H2 type
    cd18203
    Location:8 → 129
    BTB_POZ_ZBTB12; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12)
    pfam13465
    Location:373 → 398
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    35113514..35115820
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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