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Rab20 RAB20, member RAS oncogene family [ Mus musculus (house mouse) ]

Gene ID: 19332, updated on 27-Nov-2024

Summary

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Official Symbol
Rab20provided by MGI
Official Full Name
RAB20, member RAS oncogene familyprovided by MGI
Primary source
MGI:MGI:102789
See related
Ensembl:ENSMUSG00000031504 AllianceGenome:MGI:102789
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D8Ertd350e
Summary
Predicted to enable GTPase activity. Acts upstream of or within cellular response to type II interferon. Located in phagocytic vesicle. Is expressed in alimentary system; genitourinary system; heart; lung; and yolk sac. Orthologous to human RAB20 (RAB20, member RAS oncogene family). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in kidney adult (RPKM 27.8), ovary adult (RPKM 16.0) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Rab20 in Genome Data Viewer
Location:
8 A1.1; 8 5.73 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (11503390..11528640, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (11453390..11478640, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene collagen, type IV, alpha 2 Neighboring gene predicted gene, 46030 Neighboring gene STARR-seq mESC enhancer starr_20711 Neighboring gene predicted gene 15419 Neighboring gene STARR-positive B cell enhancer ABC_E8227 Neighboring gene RIKEN cDNA E230013L22 gene Neighboring gene NAD(P)HX dehydratase Neighboring gene cysteinyl-tRNA synthetase 2, mitochondrial Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:11550723-11550832

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Rab20 regulates phagosome maturation in RAW264 macrophages during Fc gamma receptor-mediated phagocytosis. Egami Y, et al. PLoS One, 2012. PMID 22545127, Free PMC Article
  2. Genetic mapping of Rab20 on mouse chromosome 8. McMurtrie EB, et al. Mamm Genome, 1997 Apr. PMID 9096117
  3. A Rab20-Dependent Membrane Trafficking Pathway Controls M. tuberculosis Replication by Regulating Phagosome Spaciousness and Integrity. Schnettger L, et al. Cell Host Microbe, 2017 May 10. PMID 28494243, Free PMC Article
  4. Expression profiling of Rab GTPases reveals the involvement of Rab20 and Rab32 in acute brain inflammation in mice. Liang Y, et al. Neurosci Lett, 2012 Oct 11. PMID 22960262
  5. The GTPase RAB20 is a HIF target with mitochondrial localization mediating apoptosis in hypoxia. Hackenbeck T, et al. Biochim Biophys Acta, 2011 Jan. PMID 21056597

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inpp5e, through functional interactions with Rab20 on the phagosome, activates Rab5, which, in turn, increases PtdIns3P and delays phagosome acidification.
    Title: Inpp5e increases the Rab5 association and phosphatidylinositol 3-phosphate accumulation at the phagosome through an interaction with Rab20.
  2. Rabs may participate in inflammatory response in microglia during brain inflammation.
    Title: Expression profiling of Rab GTPases reveals the involvement of Rab20 and Rab32 in acute brain inflammation in mice.
  3. Rab20 is an important component of phagosome and regulates the phagosome maturation during Fc gamma receptor-mediated phagocytosis.
    Title: Rab20 regulates phagosome maturation in RAW264 macrophages during Fc gamma receptor-mediated phagocytosis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC107554

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to type II interferon IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phagosome acidification ISO
Inferred from Sequence Orthology
more info
  
involved_in phagosome acidification ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phagosome-lysosome fusion ISO
Inferred from Sequence Orthology
more info
  
involved_in phagosome-lysosome fusion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in phagocytic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in phagocytic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in phagocytic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in phagocytic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ras-related protein Rab-20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011227.2 → NP_035357.1  ras-related protein Rab-20

    See identical proteins and their annotated locations for NP_035357.1

    Status: VALIDATED

    Source sequence(s)
    AC124475
    Consensus CDS
    CCDS22095.1
    UniProtKB/Swiss-Prot
    P35295
    UniProtKB/TrEMBL
    Q3TPA7, Q3ULD3, Q5FW79
    Related
    ENSMUSP00000033900.6, ENSMUST00000033900.7
    Conserved Domains (2) summary
    cd04126
    Location:7 → 232
    Rab20; Rab GTPase family 20 (Rab20)
    pfam00071
    Location:7 → 196
    Ras; Ras family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    11503390..11528640 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242042.4 → XP_011240344.1  ras-related protein Rab-20 isoform X1

    Conserved Domains (1) summary
    cl38936
    Location:11 → 185
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35295.2 GenPept UniProtKB/Swiss-Prot:P35295

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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