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Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 [ Mus musculus (house mouse) ]

Gene ID: 19289, updated on 27-Nov-2024

Summary

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Official Symbol
Igdcc3provided by MGI
Official Full Name
immunoglobulin superfamily, DCC subclass, member 3provided by MGI
Primary source
MGI:MGI:1202390
See related
Ensembl:ENSMUSG00000032394 AllianceGenome:MGI:1202390
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Punc; WI-14920; 2810401C09Rik
Summary
Acts upstream of or within neuromuscular process controlling balance. Predicted to be located in membrane. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; limb primordium; and sensory organ. Orthologous to human IGDCC3 (immunoglobulin superfamily DCC subclass member 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in CNS E11.5 (RPKM 19.1), CNS E14 (RPKM 4.0) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Igdcc3 in Genome Data Viewer
Location:
9 C; 9 35.13 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (65048404..65094313)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (65141154..65187031)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 pseudogene Neighboring gene dipeptidylpeptidase 8 Neighboring gene STARR-seq mESC enhancer starr_24441 Neighboring gene immunoglobulin superfamily, DCC subclass, member 4 Neighboring gene STARR-seq mESC enhancer starr_24448 Neighboring gene STARR-positive B cell enhancer ABC_E3840 Neighboring gene predicted gene, 40527 Neighboring gene predicted gene, 25313 Neighboring gene RNA, U5G small nuclear

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Punc, a novel mouse gene of the immunoglobulin superfamily, is expressed predominantly in the developing nervous system. Salbaum JM. Mech Dev, 1998 Feb. PMID 9507132
  2. Genomic structure and chromosomal localization of the mouse gene Punc. Salbaum JM. Mamm Genome, 1999 Feb. PMID 9922388
  3. Cloning of vertebrate Protogenin (Prtg) and comparative expression analysis during axis elongation. Vesque C, et al. Dev Dyn, 2006 Oct. PMID 16881056
  4. Cloning and expression of nope, a new mouse gene of the immunoglobulin superfamily related to guidance receptors. Salbaum JM, et al. Genomics, 2000 Feb 15. PMID 10708514
  5. Impaired motor coordination in mice that lack punc. Yang W, et al. Mol Cell Biol, 2001 Sep. PMID 11486040, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (2)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neuromuscular process controlling balance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
immunoglobulin superfamily DCC subclass member 3
Names
amplimer WI-14920, mouse homolog
putative neuronal cell adhesion molecule

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357257.1 → NP_001344186.1  immunoglobulin superfamily DCC subclass member 3 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC110235, AK011916, AK051027
    Consensus CDS
    CCDS90599.1
    UniProtKB/Swiss-Prot
    O70246, Q792T2, Q8BQC3, Q9Z2S6
    Related
    ENSMUSP00000149084.2, ENSMUST00000217371.2
    Conserved Domains (7) summary
    PRK07003
    Location:690 → 812
    PRK07003; DNA polymerase III subunit gamma/tau
    cd00063
    Location:436 → 529
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:556 → 615
    fn3; Fibronectin type III domain
    pfam07679
    Location:343 → 429
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:250 → 321
    Ig_3; Immunoglobulin domain
    cd00096
    Location:346 → 352
    Ig; Ig strand A' [structural motif]
    cl11960
    Location:53 → 147
    Ig; Immunoglobulin domain

  2. NM_008988.3 → NP_033014.1  immunoglobulin superfamily DCC subclass member 3 isoform 2 precursor

    See identical proteins and their annotated locations for NP_033014.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC110235, AC161366
    Consensus CDS
    CCDS52835.1
    UniProtKB/Swiss-Prot
    Q8BQC3
    Related
    ENSMUSP00000034961.5, ENSMUST00000034961.6
    Conserved Domains (5) summary
    smart00410
    Location:157 → 239
    IG_like; Immunoglobulin like
    cd00063
    Location:436 → 529
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:343 → 429
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:565 → 615
    fn3; Fibronectin type III domain
    cl11960
    Location:56 → 147
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    65048404..65094313
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242679.3 → XP_011240981.2  immunoglobulin superfamily DCC subclass member 3 isoform X1

    Conserved Domains (7) summary
    PRK07003
    Location:569 → 691
    PRK07003; DNA polymerase III subunit gamma/tau
    cd00063
    Location:315 → 408
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:435 → 494
    fn3; Fibronectin type III domain
    pfam07679
    Location:222 → 308
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:129 → 200
    Ig_3; Immunoglobulin domain
    cd00096
    Location:225 → 231
    Ig; Ig strand A' [structural motif]
    cl11960
    Location:37 → 118
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BQC3.1 GenPept UniProtKB/Swiss-Prot:Q8BQC3

Gene LinkOut

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