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Wbp2 WW domain binding protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 192645, updated on 4-Jan-2025

Summary

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Official Symbol
Wbp2provided by RGD
Official Full Name
WW domain binding protein 2provided by RGD
Primary source
RGD:620032
See related
EnsemblRapid:ENSRNOG00000007971 AllianceGenome:RGD:620032
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA binding activity; nuclear estrogen receptor binding activity; and transcription coactivator activity. Predicted to be involved in several processes, including cellular response to estrogen stimulus; positive regulation of intracellular estrogen receptor signaling pathway; and positive regulation of macromolecule biosynthetic process. Predicted to be located in chromatin; cytosol; and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 107. Orthologous to human WBP2 (WW domain binding protein 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Brain (RPKM 126.4), Kidney (RPKM 96.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Wbp2 in Genome Data Viewer
Location:
10q32.1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (101811308..101819766, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (101312476..101320775, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (104629563..104637906, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480906 Neighboring gene unk zinc finger Neighboring gene unc-13 homolog D Neighboring gene uncharacterized LOC102552044 Neighboring gene uncharacterized LOC120093105 Neighboring gene tripartite motif-containing 47 Neighboring gene tripartite motif-containing 65

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular mechanism of WW-domain binding protein-2 coactivation function in estrogen receptor signaling. Buffa L, et al. IUBMB Life, 2013 Jan. PMID 23233354
  2. Tyrosine phosphorylation of transcriptional coactivator WW-domain binding protein 2 regulates estrogen receptor α function in breast cancer via the Wnt pathway. Lim SK, et al. FASEB J, 2011 Sep. PMID 21642474
  3. WBP-2, a WW domain binding protein, interacts with the thyroid-specific transcription factor Pax8. Nitsch R, et al. Biochem J, 2004 Feb 1. PMID 14531730, Free PMC Article
  4. Characterization of the WW domain of human yes-associated protein and its polyproline-containing ligands. Chen HI, et al. J Biol Chem, 1997 Jul 4. PMID 9202023
  5. WW domain binding protein-2, an E6-associated protein interacting protein, acts as a coactivator of estrogen and progesterone receptors. Dhananjayan SC, et al. Mol Endocrinol, 2006 Oct. PMID 16772533

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear estrogen receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription coactivator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cellular response to estrogen stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to estrogen stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment of protein localization to chromatin IEA
Inferred from Electronic Annotation
more info
  
involved_in establishment of protein localization to chromatin ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of intracellular estrogen receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of intracellular estrogen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of intracellular estrogen receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in progesterone receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in progesterone receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in progesterone receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to estrogen ISO
Inferred from Sequence Orthology
more info
  
involved_in response to estrogen ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to progesterone IEA
Inferred from Electronic Annotation
more info
  
involved_in response to progesterone ISO
Inferred from Sequence Orthology
more info
  
involved_in response to progesterone ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in transcription initiation-coupled chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription initiation-coupled chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in chromatin IEA
Inferred from Electronic Annotation
more info
  
located_in chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
WW domain-binding protein 2
Names
WBP-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138975.1 → NP_620431.1  WW domain-binding protein 2

    See identical proteins and their annotated locations for NP_620431.1

    Status: PROVISIONAL

    Source sequence(s)
    AF499026
    UniProtKB/Swiss-Prot
    Q8R478
    Conserved Domains (1) summary
    cd13214
    Location:30 → 131
    PH-GRAM_WBP2; WW binding protein 2 (WB2) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    101811308..101819766 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006247705.5 → XP_006247767.1  WW domain-binding protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A8I6A0C5
    Related
    ENSRNOP00000084989.1, ENSRNOT00000097406.2
    Conserved Domains (1) summary
    cd13214
    Location:30 → 131
    PH-GRAM_WBP2; WW binding protein 2 (WB2) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

  2. XM_017596983.3 → XP_017452472.1  WW domain-binding protein 2 isoform X2

    Conserved Domains (1) summary
    cd13214
    Location:30 → 131
    PH-GRAM_WBP2; WW binding protein 2 (WB2) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

  3. XM_039085162.2 → XP_038941090.1  WW domain-binding protein 2 isoform X1

    UniProtKB/TrEMBL
    G3V721
    Related
    ENSRNOP00000010826.3, ENSRNOT00000010826.5
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R478.1 GenPept UniProtKB/Swiss-Prot:Q8R478

Gene LinkOut

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