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cct3 chaperonin containing TCP1, subunit 3 (gamma) [ Danio rerio (zebrafish) ]

Gene ID: 192327, updated on 9-Dec-2024

Summary

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Official Symbol
cct3provided by ZNC
Official Full Name
chaperonin containing TCP1, subunit 3 (gamma)provided by ZNC
Primary source
ZFIN:ZDB-GENE-020419-5
See related
Ensembl:ENSDARG00000016173 AllianceGenome:ZFIN:ZDB-GENE-020419-5
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
chunp6930; wu:fb13f04; wu:fb52a02; wu:fj48b06
Summary
Predicted to enable unfolded protein binding activity. Acts upstream of or within embryonic eye morphogenesis and negative regulation of retinal cell programmed cell death. Predicted to be part of chaperonin-containing T-complex. Orthologous to human CCT3 (chaperonin containing TCP1 subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See cct3 in Genome Data Viewer
Location:
chromosome: 16
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (30408787..30421207, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (30450860..30463280, complement)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene cortexin-2 Neighboring gene transmembrane protein 79b Neighboring gene protein disulfide isomerase family A, member 7 Neighboring gene platelet endothelial aggregation receptor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Mob4-dependent STRIPAK involves the chaperonin TRiC to coordinate myofibril and microtubule network growth. Berger J, et al. PLoS Genet, 2022 Jun. PMID 35737712, Free PMC Article
  2. In Vivo Function of the Chaperonin TRiC in α-Actin Folding during Sarcomere Assembly. Berger J, et al. Cell Rep, 2018 Jan 9. PMID 29320728
  3. A cellular retinoic acid-binding protein from zebrafish (Danio rerio): cDNA sequence, phylogenetic analysis, mRNA expression, and gene linkage mapping. Sharma MK, et al. Gene, 2003 Jun 5. PMID 12853146
  4. Identification of chaperonin CCT gamma subunit as a determinant of retinotectal development by whole-genome subtraction cloning from zebrafish no tectal neuron mutant. Matsuda N, et al. Development, 2004 May. PMID 15056614
  5. Transcriptomic responses of S100 family to bacterial and viral infection in zebrafish. Zhang C, et al. Fish Shellfish Immunol, 2019 Nov. PMID 31546038

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results suggest that the gamma subunit of chaperonin CCT plays an essential role in retinotectal development.
    Title: Identification of chaperonin CCT gamma subunit as a determinant of retinotectal development by whole-genome subtraction cloning from zebrafish no tectal neuron mutant.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within embryonic eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of retinal cell programmed cell death IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein folding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of chaperonin-containing T-complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
T-complex protein 1 subunit gamma
Names
no tectal neuron
ntn
subunit 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173250.1 → NP_775357.1  T-complex protein 1 subunit gamma

    See identical proteins and their annotated locations for NP_775357.1

    Status: PROVISIONAL

    Source sequence(s)
    AF506209
    UniProtKB/TrEMBL
    Q8JHI7
    Related
    ENSDARP00000004738.7, ENSDART00000003752.9
    Conserved Domains (2) summary
    cd03337
    Location:5 → 524
    TCP1_gamma; TCP-1 (CTT or eukaryotic type II) chaperonin family, gamma subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...
    TIGR02344
    Location:5 → 528
    chap_CCT_gamma; T-complex protein 1, gamma subunit

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    30408787..30421207 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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