ncbp2 nuclear cap binding protein subunit 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ncbp2provided by ZNC
Official Full Name: nuclear cap binding protein subunit 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-020419-31
See related: Ensembl:ENSDARG00000014898 AllianceGenome:ZFIN:ZDB-GENE-020419-31
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: CHUNP6917; zgc:92592
Summary: Predicted to enable RNA 7-methylguanosine cap binding activity; mRNA binding activity; and snRNA binding activity. Predicted to be involved in mRNA cis splicing, via spliceosome; positive regulation of RNA export from nucleus; and snRNA export from nucleus. Predicted to act upstream of or within mRNA processing; mRNA transport; and regulation of gene expression. Predicted to be located in cytoplasm and nucleus. Predicted to be part of nuclear cap binding activity complex. Orthologous to several human genes including NCBP2 (nuclear cap binding protein subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (38930731..38934776, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (38943986..38948031, complement)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA 7-methylguanosine cap binding	ISS Inferred from Sequence or Structural Similarity more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA cap binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA cap binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables snRNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in RNA splicing	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within mRNA cis splicing, via spliceosome	IEA Inferred from Electronic Annotation more info
involved_in mRNA cis splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mRNA transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of RNA export from nucleus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of translation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulatory ncRNA-mediated gene silencing	IEA Inferred from Electronic Annotation more info
involved_in snRNA export from nucleus	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of nuclear cap binding complex	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear cap binding complex	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nuclear cap-binding protein subunit 2

Names: 20 kDa nuclear cap-binding protein; CBP20; NCBP 20 kDa subunit; nuclear cap binding protein subunit 2, 20kD

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173249.1 → NP_775356.1 nuclear cap-binding protein subunit 2

See identical proteins and their annotated locations for NP_775356.1

Status: PROVISIONAL

Source sequence(s)

AY099530

UniProtKB/Swiss-Prot

Q1MT38, Q5XIY9, Q8JGR6

Related

ENSDARP00000020688.7, ENSDART00000008365.9

Conserved Domains (2) summary

COG0724
Location:36 → 139

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12240
Location:41 → 118

RRM_NCBP2; RNA recognition motif found in nuclear cap-binding protein subunit 2 (CBP20) and similar proteins