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slc25a5 solute carrier family 25 member 5 [ Danio rerio (zebrafish) ]

Gene ID: 192321, updated on 19-Jan-2025

Summary

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Official Symbol
slc25a5provided by ZNC
Official Full Name
solute carrier family 25 member 5provided by ZNC
Primary source
ZFIN:ZDB-GENE-020419-9
See related
Ensembl:ENSDARG00000092553 AllianceGenome:ZFIN:ZDB-GENE-020419-9
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
CHUNP6931; sr:nyz040; wu:fe06b05; SI:bZ46J2.1; SI:bZ46J2.3; SI:bZ46J2.5; SI:bZ46J2.6; SI:bZ46J2.7; SI:bZ46J2.9; si:bz46j2.2
Summary
Predicted to enable ATP:ADP antiporter activity. Predicted to be involved in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. Predicted to act upstream of or within mitochondrial ADP transmembrane transport and mitochondrial ATP transmembrane transport. Predicted to be located in mitochondrial inner membrane. Is expressed in several structures, including bone element; eye; female organism; integument; and male organism. Orthologous to human SLC25A5 (solute carrier family 25 member 5). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See slc25a5 in Genome Data Viewer
Location:
chromosome: 14
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (32881627..32884069, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (32541310..32543801, complement)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene si:rp71-46j2.7 Neighboring gene ubiquitin-conjugating enzyme E2A (RAD6 homolog) Neighboring gene si:rp71-46j2.8 Neighboring gene solute carrier family 25 member 43 Neighboring gene ligand of numb-protein X 2b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Unsuccessful attempt at gene-editing by homologous recombination in the zebrafish germ line using the approach of "Rong and Golic". Brookfield R, et al. Transgenic Res, 2012 Oct. PMID 22434322, Free PMC Article
  2. Differentially sensitive neuronal subpopulations in the central nervous system and the formation of hindbrain heterotopias in ethanol-exposed zebrafish. Buckley DM, et al. Birth Defects Res, 2019 Jul 15. PMID 30793540, Free PMC Article
  3. Chronic unpredictable stress (CUS)-induced anxiety and related mood disorders in a zebrafish model: altered brain proteome profile implicates mitochondrial dysfunction. Chakravarty S, et al. PLoS One, 2013. PMID 23691016, Free PMC Article
  4. Llgl1 mediates timely epicardial emergence and establishment of an apical laminin sheath around the trabeculating cardiac ventricle. Pollitt EJG, et al. Development, 2024 Jul 1. PMID 38940292, Free PMC Article
  5. Identification of housekeeping genes suitable for gene expression analysis in the zebrafish. Casadei R, et al. Gene Expr Patterns, 2011 Mar-Apr. PMID 21281742

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP:ADP antiporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within mitochondrial ADP transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mitochondrial ATP transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ADP/ATP translocase 2
Names
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
solute carrier family 25 alpha, member 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173247.1 → NP_775354.1  ADP/ATP translocase 2

    See identical proteins and their annotated locations for NP_775354.1

    Status: PROVISIONAL

    Source sequence(s)
    AF506216
    UniProtKB/TrEMBL
    A7MCM1, F6P6T8, Q8JHI0
    Related
    ENSDARP00000096504.3, ENSDART00000105726.4
    Conserved Domains (2) summary
    PTZ00169
    Location:7 → 298
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:6 → 101
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    32881627..32884069 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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