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terfa telomeric repeat binding factor a [ Danio rerio (zebrafish) ]

Gene ID: 192316, updated on 4-Jan-2025

Summary

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Official Symbol
terfaprovided by ZNC
Official Full Name
telomeric repeat binding factor aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-020419-38
See related
Ensembl:ENSDARG00000039302 AllianceGenome:ZFIN:ZDB-GENE-020419-38
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
CHUNP6903; wu:fi15d05; wu:fi22b03; zgc:111909; zgc:114011
Summary
Enables telomeric DNA binding activity. Predicted to act upstream of or within protection from non-homologous end joining at telomere. Predicted to be located in chromosome, telomeric region and nucleus. Is expressed in several structures, including gill; heart; liver; nervous system; and pleuroperitoneal region. Orthologous to human TERF2 (telomeric repeat binding factor 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See terfa in Genome Data Viewer
Location:
chromosome: 4
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (77973874..77996958)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (76589172..76612256)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene ADP-ribosylation factor GTPase activating protein 3 Neighboring gene IKBKB interacting protein Neighboring gene cytoskeleton associated protein 4 Neighboring gene ras-related protein Rab-19-like Neighboring gene zgc:194336 Neighboring gene T-complex protein 1 subunit beta-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Solution structure of the Myb domain of Terfa derived from Zebrafish interacting with both human and plant telomeric DNA. Kim MJ, et al. Biochem Biophys Res Commun, 2021 Jun 25. PMID 33984809
  2. Sleep increases chromosome dynamics to enable reduction of accumulating DNA damage in single neurons. Zada D, et al. Nat Commun, 2019 Mar 5. PMID 30837464, Free PMC Article
  3. The knockdown efficiency of telomere associated genes with specific methodology in a zebrafish cell line. Hu X, et al. Biochimie, 2021 Nov. PMID 34214617
  4. p53 upregulation is a frequent response to deficiency of cell-essential genes. Danilova N, et al. PLoS One, 2010 Dec 31. PMID 21209837, Free PMC Article
  5. The differential spatiotemporal expression pattern of shelterin genes throughout lifespan. Wagner KD, et al. Aging (Albany NY), 2017 Apr. PMID 28437249, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Solution structure of the Myb domain of Terfa derived from Zebrafish interacting with both human and plant telomeric DNA.
    Title: Solution structure of the Myb domain of Terfa derived from Zebrafish interacting with both human and plant telomeric DNA.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC111909, MGC114011, MGC192548

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables telomeric DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables telomeric DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within protection from non-homologous end joining at telomere IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within telomere maintenance IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
telomeric repeat binding factor a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173243.2 → NP_775350.2  telomeric repeat binding factor a

    Status: VALIDATED

    Source sequence(s)
    CU695140
    UniProtKB/TrEMBL
    A0A8N7UZT2, F1Q8U5, F1QRC8, Q4FZZ9
    Related
    ENSDARP00000057422.5, ENSDART00000057423.8
    Conserved Domains (3) summary
    smart00717
    Location:524 → 570
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11660
    Location:522 → 570
    SANT_TRF; Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family
    cd00280
    Location:7 → 203
    TRFH; Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain Homology; TRFH. Telomeres are protein/DNA complexes that make up the physical ends of eukaryotic linear chromosomes and are essential for chromosome stability, ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    77973874..77996958
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009301103.4 → XP_009299378.1  telomeric repeat binding factor a isoform X1

    UniProtKB/TrEMBL
    A0A8M3ART8, Q4FZZ9
    Conserved Domains (3) summary
    smart00717
    Location:560 → 606
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11660
    Location:558 → 606
    SANT_TRF; Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family
    cd00280
    Location:7 → 203
    TRFH; Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain Homology; TRFH. Telomeres are protein/DNA complexes that make up the physical ends of eukaryotic linear chromosomes and are essential for chromosome stability, ...

  2. XM_068219508.1 → XP_068075609.1  telomeric repeat binding factor a isoform X3

    UniProtKB/TrEMBL
    Q8JGS4

  3. XM_021474924.2 → XP_021330599.1  telomeric repeat binding factor a isoform X5

    UniProtKB/TrEMBL
    A0A8M9Q073, Q8JGS4
    Conserved Domains (2) summary
    cd11660
    Location:493 → 541
    SANT_TRF; Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family
    cd00280
    Location:7 → 203
    TRFH; Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain Homology; TRFH. Telomeres are protein/DNA complexes that make up the physical ends of eukaryotic linear chromosomes and are essential for chromosome stability, ...

  4. XM_068219510.1 → XP_068075611.1  telomeric repeat binding factor a isoform X6

    UniProtKB/TrEMBL
    Q8JGS4

  5. XM_021474925.2 → XP_021330600.1  telomeric repeat binding factor a isoform X7

    UniProtKB/TrEMBL
    A0A8M9QAZ0, Q8JGS4
    Conserved Domains (2) summary
    cd11660
    Location:457 → 505
    SANT_TRF; Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family
    cd00280
    Location:7 → 203
    TRFH; Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain Homology; TRFH. Telomeres are protein/DNA complexes that make up the physical ends of eukaryotic linear chromosomes and are essential for chromosome stability, ...

  6. XM_009301104.4 → XP_009299379.1  telomeric repeat binding factor a isoform X2

    UniProtKB/TrEMBL
    A0A8M3B9A0, Q4FZZ9
    Conserved Domains (3) summary
    smart00717
    Location:559 → 605
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11660
    Location:557 → 605
    SANT_TRF; Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family
    cd00280
    Location:7 → 202
    TRFH; Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain Homology; TRFH. Telomeres are protein/DNA complexes that make up the physical ends of eukaryotic linear chromosomes and are essential for chromosome stability, ...

  7. XM_068219509.1 → XP_068075610.1  telomeric repeat binding factor a isoform X4

    UniProtKB/TrEMBL
    Q4FZZ9
Nucleotide Protein Strain
Heading Accession and Version

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