Tmem47 transmembrane protein 47 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmem47provided by MGI
Official Full Name: transmembrane protein 47provided by MGI
Primary source: MGI:MGI:2177570
See related: Ensembl:ENSMUSG00000025666 AllianceGenome:MGI:2177570
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BCMP1; Tm4sf10; 3010015F07Rik
Summary: Predicted to be involved in cell-cell adhesion. Located in cell-cell junction. Is expressed in metanephros; musculature; telencephalon; ventral grey horn; and ventricular layer. Orthologous to human TMEM47 (transmembrane protein 47). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in frontal lobe adult (RPKM 15.1), cortex adult (RPKM 14.7) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: X B; X 38.38 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (80114250..80141481)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (81070644..81097875)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TM4SF10, possibly through ADAP, may regulate Fyn activity
Title: TM4SF10 and ADAP interaction in podocytes: role in Fyn activity and nephrin phosphorylation.
TM4SF10 functions during differentiation of podocytes and may participate in the maturation of cell junctions from simple adherens junctions to elaborate slit diaphragms.
Title: Expression of TM4SF10, a Claudin/EMP/PMP22 family cell junction protein, during mouse kidney development and podocyte differentiation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

px-38h7 (e-PCR)
- UniSTS:243303

px-7e3 (e-PCR)
- UniSTS:258197

DXMit111 (e-PCR), detects polymorphism
- UniSTS:132001

DXMit112 (e-PCR), detects polymorphism
- UniSTS:132002

RH135885 (e-PCR)
- UniSTS:209883

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in adherens junction	IEA Inferred from Electronic Annotation more info
is_active_in cell-cell junction	IBA Inferred from Biological aspect of Ancestor more info
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transmembrane protein 47

Names: transmembrane 4 superfamily member 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.