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Sardh sarcosine dehydrogenase [ Mus musculus (house mouse) ]

Gene ID: 192166, updated on 27-Nov-2024

Summary

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Official Symbol
Sardhprovided by MGI
Official Full Name
sarcosine dehydrogenaseprovided by MGI
Primary source
MGI:MGI:2183102
See related
Ensembl:ENSMUSG00000009614 AllianceGenome:MGI:2183102
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable flavin adenine dinucleotide binding activity; folic acid binding activity; and sarcosine dehydrogenase activity. Predicted to be involved in sarcosine catabolic process and tetrahydrofolate interconversion. Located in mitochondrion. Is expressed in brain; future brain; hepatic primordium; and liver. Human ortholog(s) of this gene implicated in sarcosinemia. Orthologous to human SARDH (sarcosine dehydrogenase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in liver adult (RPKM 211.5), kidney adult (RPKM 72.0) and 2 other tissues See more
Orthologs
human all
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Genomic context

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See Sardh in Genome Data Viewer
Location:
2 A3; 2 19.31 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (27078405..27138344, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (27188393..27248332, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene dopamine beta hydroxylase, opposite strand Neighboring gene dopamine beta hydroxylase Neighboring gene vav 2 oncogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:27159262-27159371 Neighboring gene Vav2R10 erythroid cis-regulatory module Neighboring gene Vav2R3 erythroid cis-regulatory module Neighboring gene STARR-seq mESC enhancer starr_04000 Neighboring gene Vav2R7 erythroid cis-regulatory module Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:27269900-27270101 Neighboring gene STARR-seq mESC enhancer starr_04002 Neighboring gene Vav2R5 erythroid cis-regulatory module Neighboring gene bromodomain containing 3, opposite strand

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. sar: a genetic mouse model for human sarcosinemia generated by ethylnitrosourea mutagenesis. Harding CO, et al. Proc Natl Acad Sci U S A, 1992 Apr 1. PMID 1372986, Free PMC Article
  2. Endogenous formaldehyde is a memory-related molecule in mice and humans. Ai L, et al. Commun Biol, 2019. PMID 31815201, Free PMC Article
  3. Identification and characterization of proteins interacting with Traf4, an enigmatic p53 target. Rozan LM, et al. Cancer Biol Ther, 2006 Sep. PMID 16969126
  4. Liver and brain differential expression of one-carbon metabolism genes during ontogenesis. Imbard A, et al. Sci Rep, 2021 Oct 26. PMID 34702858, Free PMC Article
  5. Essential roles of mitochondrial biogenesis regulator Nrf1 in retinal development and homeostasis. Kiyama T, et al. Mol Neurodegener, 2018 Oct 17. PMID 30333037, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC6279

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables flavin adenine dinucleotide binding ISO
Inferred from Sequence Orthology
more info
  
enables folic acid binding ISO
Inferred from Sequence Orthology
more info
  
enables sarcosine dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sarcosine dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables sarcosine dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in sarcosine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tetrahydrofolate interconversion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
sarcosine dehydrogenase, mitochondrial
NP_619606.1
XP_006497851.1
XP_006497852.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138665.2 → NP_619606.1  sarcosine dehydrogenase, mitochondrial

    See identical proteins and their annotated locations for NP_619606.1

    Status: VALIDATED

    Source sequence(s)
    AK163515, AL731552, AW495221
    Consensus CDS
    CCDS15826.1
    UniProtKB/Swiss-Prot
    Q99LB7
    UniProtKB/TrEMBL
    Q3TQD9, Q3TWI2
    Related
    ENSMUSP00000099950.4, ENSMUST00000102886.10
    Conserved Domains (3) summary
    COG0404
    Location:480 → 917
    GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
    COG0665
    Location:64 → 448
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
    pfam16350
    Location:431 → 486
    FAO_M; FAD dependent oxidoreductase central domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    27078405..27138344 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497789.5 → XP_006497852.1  sarcosine dehydrogenase, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006497852.1

    UniProtKB/Swiss-Prot
    Q99LB7
    UniProtKB/TrEMBL
    Q3TQD9, Q3TWI2
    Conserved Domains (3) summary
    COG0404
    Location:480 → 917
    GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
    COG0665
    Location:64 → 448
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
    pfam16350
    Location:431 → 486
    FAO_M; FAD dependent oxidoreductase central domain

  2. XM_006497788.5 → XP_006497851.1  sarcosine dehydrogenase, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006497851.1

    UniProtKB/Swiss-Prot
    Q99LB7
    UniProtKB/TrEMBL
    Q3TQD9, Q3TWI2
    Conserved Domains (3) summary
    COG0404
    Location:480 → 917
    GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
    COG0665
    Location:64 → 448
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
    pfam16350
    Location:431 → 486
    FAO_M; FAD dependent oxidoreductase central domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99LB7.1 GenPept UniProtKB/Swiss-Prot:Q99LB7

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