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Hip1 huntingtin interacting protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 192154, updated on 27-Nov-2024

Summary

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Official Symbol
Hip1provided by RGD
Official Full Name
huntingtin interacting protein 1provided by RGD
Primary source
RGD:620305
See related
EnsemblRapid:ENSRNOG00000001448 AllianceGenome:RGD:620305
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables clathrin binding activity. Involved in clathrin coat assembly. Located in clathrin-coated vesicle and presynaptic membrane. Is active in glutamatergic synapse; postsynaptic membrane; and presynapse. Orthologous to human HIP1 (huntingtin interacting protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 168.4), Lung (RPKM 147.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Hip1 in Genome Data Viewer
Location:
12q12
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (26769868..26904367)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (21133364..21267796)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (24180795..24315373)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene C-C motif chemokine ligand 26 Neighboring gene ribosomal protein S13, pseudogene 4 Neighboring gene uncharacterized LOC120095918 Neighboring gene uncharacterized LOC134481279 Neighboring gene uncharacterized LOC134481281 Neighboring gene uncharacterized LOC120095917

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Huntingtin interacting protein 1 induces apoptosis via a novel caspase-dependent death effector domain. Hackam AS, et al. J Biol Chem, 2000 Dec 29. PMID 11007801
  2. The Sla2p/HIP1/HIP1R family: similar structure, similar function in endocytosis? Gottfried I, et al. Biochem Soc Trans, 2010 Feb. PMID 20074057
  3. Clathrin- and AP-2-binding sites in HIP1 uncover a general assembly role for endocytic accessory proteins. Mishra SK, et al. J Biol Chem, 2001 Dec 7. PMID 11577110
  4. Partially overlapping distribution of epsin1 and HIP1 at the synapse: analysis by immunoelectron microscopy. Yao PJ, et al. J Comp Neurol, 2006 Jan 10. PMID 16320245
  5. Regulation of the proapoptotic activity of huntingtin interacting protein 1 by Dyrk1 and caspase-3 in hippocampal neuroprogenitor cells. Kang JE, et al. J Neurosci Res, 2005 Jul 1. PMID 15906374

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. KIF1C and new Huntingtin-interacting protein 1 binding proteins regulate rheumatoid arthritis fibroblast-like synoviocytes' phenotypes.
    Title: KIF1C and new Huntingtin-interacting protein 1 binding proteins regulate rheumatoid arthritis fibroblast-like synoviocytes' phenotypes.
  2. HIP1 and HIP12 display differential binding to F-actin, AP2, and clathrin. Identification of a novel interaction with clathrin light chain.
    Title: HIP1 and HIP12 display differential binding to F-actin, AP2, and clathrin. Identification of a novel interaction with clathrin light chain.
  3. epsin1 is located across both sides of the synapse, whereas HIP1 displays a preference for the postsynaptic compartment; results suggest a dual role for epsin1 and huntingtin-interacting protein 1 in the synapse
    Title: Partially overlapping distribution of epsin1 and HIP1 at the synapse: analysis by immunoelectron microscopy.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables AP-2 adaptor complex binding ISO
Inferred from Sequence Orthology
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
  
enables clathrin adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables clathrin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables clathrin binding ISO
Inferred from Sequence Orthology
more info
  
enables clathrin light chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables clathrin light chain binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3,4-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3,4-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3-phosphate binding ISO
Inferred from Sequence Orthology
more info
  
NOT enables phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in clathrin coat assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in clathrin coat assembly IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within clathrin coat assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in clathrin coat assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in endocytosis TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within positive regulation of cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of platelet-derived growth factor receptor-beta signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of platelet-derived growth factor receptor-beta signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in presynaptic modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of postsynaptic neurotransmitter receptor internalization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in clathrin-coated vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in clathrin-coated vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in clathrin-coated vesicle ISO
Inferred from Sequence Orthology
more info
  
is_active_in cortical actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynapse IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in presynapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in presynapse ISO
Inferred from Sequence Orthology
more info
  
located_in presynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
huntingtin-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100475.1 → NP_001093945.1  huntingtin-interacting protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001093945.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473973
    UniProtKB/TrEMBL
    A0A8I6GA90, A6J0C8
    Related
    ENSRNOP00000031153.6, ENSRNOT00000030497.6
    Conserved Domains (5) summary
    smart00307
    Location:807 → 1005
    ILWEQ; I/LWEQ domain
    pfam07651
    Location:37 → 308
    ANTH; ANTH domain
    pfam07926
    Location:433 → 550
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam14335
    Location:336 → 441
    DUF4391; Domain of unknown function (DUF4391)
    pfam16515
    Location:482 → 572
    HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1

  2. NM_001415756.1 → NP_001402685.1  huntingtin-interacting protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    G3V8Y8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    26769868..26904367
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063271032.1 → XP_063127102.1  huntingtin-interacting protein 1 isoform X2

    UniProtKB/TrEMBL
    G3V8Y8
    Related
    ENSRNOP00000083048.2, ENSRNOT00000119935.2

  2. XM_063271033.1 → XP_063127103.1  huntingtin-interacting protein 1 isoform X2

    UniProtKB/TrEMBL
    G3V8Y8

  3. XM_063271034.1 → XP_063127104.1  huntingtin-interacting protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A8I6AA26

  4. XM_006249100.5 → XP_006249162.1  huntingtin-interacting protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A8I6AA26, A6J0C9
    Related
    ENSRNOP00000088574.1, ENSRNOT00000098638.2
    Conserved Domains (4) summary
    smart00307
    Location:781 → 979
    ILWEQ; I/LWEQ domain
    pfam07651
    Location:7 → 274
    ANTH; ANTH domain
    pfam14335
    Location:302 → 407
    DUF4391; Domain of unknown function (DUF4391)
    pfam16515
    Location:448 → 546
    HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1

  5. XM_006249099.5 → XP_006249161.1  huntingtin-interacting protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I5Y6T0, A6J0C9
    Related
    ENSRNOP00000078035.1, ENSRNOT00000104382.2
    Conserved Domains (4) summary
    smart00307
    Location:785 → 983
    ILWEQ; I/LWEQ domain
    pfam07651
    Location:11 → 278
    ANTH; ANTH domain
    pfam14335
    Location:306 → 411
    DUF4391; Domain of unknown function (DUF4391)
    pfam16515
    Location:452 → 550
    HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1

  6. XM_017598252.3 → XP_017453741.1  huntingtin-interacting protein 1 isoform X1

    UniProtKB/TrEMBL
    A6J0C9
    Related
    ENSRNOP00000100363.1, ENSRNOT00000158458.1
    Conserved Domains (4) summary
    smart00307
    Location:826 → 1024
    ILWEQ; I/LWEQ domain
    COG1196
    Location:396 → 655
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam07651
    Location:52 → 317
    ANTH; ANTH domain
    pfam16515
    Location:499 → 591
    HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1

  7. XM_017598253.2 → XP_017453742.1  huntingtin-interacting protein 1 isoform X1

    UniProtKB/TrEMBL
    A6J0C9
    Conserved Domains (4) summary
    smart00307
    Location:826 → 1024
    ILWEQ; I/LWEQ domain
    COG1196
    Location:396 → 655
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam07651
    Location:52 → 317
    ANTH; ANTH domain
    pfam16515
    Location:499 → 591
    HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1

  8. XM_039089055.1 → XP_038944983.1  huntingtin-interacting protein 1 isoform X1

    UniProtKB/TrEMBL
    A6J0C9
    Conserved Domains (4) summary
    smart00307
    Location:826 → 1024
    ILWEQ; I/LWEQ domain
    COG1196
    Location:396 → 655
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam07651
    Location:52 → 317
    ANTH; ANTH domain
    pfam16515
    Location:499 → 591
    HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1

  9. XM_063271036.1 → XP_063127106.1  huntingtin-interacting protein 1 isoform X5

  10. XM_063271035.1 → XP_063127105.1  huntingtin-interacting protein 1 isoform X5

Nucleotide Protein Strain
Heading Accession and Version

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