zig-3 Zwei Ig domain protein zig-3 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: zig-3
Official Full Name: Zwei Ig domain protein zig-3
Primary source: WormBase:WBGene00006980
Locus tag: CELE_C14F5.2
See related: AllianceGenome:WB:WBGene00006980
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable cell-cell adhesion mediator activity. Predicted to be involved in axon guidance; dendrite self-avoidance; and homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to be located in extracellular region. Predicted to be active in axon and plasma membrane. Is expressed in ASI; body wall musculature; nerve ring neurons; and vulva. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See zig-3 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 3

Sequence:: Chromosome: X; NC_003284.9 (7930750..7931808)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Double mutant analysis shows that zig-3 and zig-4 act together to affect axon maintenance, yet they are not functionally interchangeable.
Title: The small, secreted immunoglobulin protein ZIG-3 maintains axon position in Caenorhabditis elegans.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C14F5.2 (e-PCR)
- UniSTS:312165

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables cell-cell adhesion mediator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendrite self-avoidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Zwei Ig domain protein zig-3

NP_509336.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

7930750..7931808

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_076935.7 → NP_509336.1 Zwei Ig domain protein zig-3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_509336.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EEY6

Conserved Domains (4) summary

cd00096
Location:61 → 142

Ig; Immunoglobulin domain

smart00410
Location:177 → 244

IG_like; Immunoglobulin like

pfam07679
Location:45 → 145

I-set; Immunoglobulin I-set domain

cl11960
Location:191 → 237

Ig; Immunoglobulin domain