U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

twk-4 Potassium channel domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 192079, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
twk-4
Official Full Name
Potassium channel domain-containing protein
Primary source
WormBase:WBGene00006659
Locus tag
CELE_ZK1067.5
See related
AllianceGenome:WB:WBGene00006659
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable outward rectifier potassium channel activity and potassium ion leak channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in sensory neurons. [provided by Alliance of Genome Resources, Jan 2025]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See twk-4 in Genome Data Viewer
Location:
chromosome: II
Exon count:
15
Sequence:
Chromosome: II; NC_003280.10 (9178514..9194295, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Calcineurin-like phosphoesterase domain-containing protein Neighboring gene Transcription factor dpl-1 Neighboring gene Exocyst complex component 2 Neighboring gene RNA/RNP complex-1-interacting phosphatase homolog Neighboring gene RNA-binding protein sym-2;RRM domain-containing protein Neighboring gene Receptor tyrosine-protein kinase let-23;receptor protein-tyrosine kinase Neighboring gene ncRNA Neighboring gene Transmembrane protein 151 homolog Neighboring gene ncRNA Neighboring gene tRNA-Tyr

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Structure and function of two-pore-domain K+ channels: contributions from genetic model organisms. Buckingham SD, et al. Trends Pharmacol Sci, 2005 Jul. PMID 15939489
  2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables outward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium ion leak channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Potassium channel domain-containing protein
NP_001343566.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    9178514..9194295 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001356885.3 → NP_001343566.1  Potassium channel domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q23386
    Conserved Domains (1) summary
    pfam07885
    Location:178 → 235
    Ion_trans_2; Ion channel
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools