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nhr-85 Nuclear hormone receptor family member nhr-85 [ Caenorhabditis elegans ]

Gene ID: 191732, updated on 4-Jan-2025

Summary

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Official Symbol
nhr-85
Official Full Name
Nuclear hormone receptor family member nhr-85
Primary source
WormBase:WBGene00003675
Locus tag
CELE_W05B5.3
See related
AllianceGenome:WB:WBGene00003675
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Predicted to be involved in cell differentiation; hormone-mediated signaling pathway; and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in excretory duct cell; hypodermis; vulva; and vulval precursor cell. Human ortholog(s) of this gene implicated in brain small vessel disease and type 2 diabetes mellitus. Orthologous to several human genes including NR1D1 (nuclear receptor subfamily 1 group D member 1) and NR1D2 (nuclear receptor subfamily 1 group D member 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See nhr-85 in Genome Data Viewer
Location:
chromosome: I
Exon count:
7
Sequence:
Chromosome: I; NC_003279.8 (13055201..13062122, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Calcium-transporting ATPase Neighboring gene Uncharacterized protein Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene PAN-3 domain-containing protein Neighboring gene C-type lectin domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An nhr-85::GFP::AID*::3xFLAG knock-in allele for investigation of molting and oscillatory gene regulation. Myles KM, et al. MicroPubl Biol, 2023. PMID 37927911, Free PMC Article
  2. A circadian-like gene network programs the timing and dosage of heterochronic miRNA transcription during C. elegans development. Kinney B, et al. Dev Cell, 2023 Nov 20. PMID 37643611, Free PMC Article
  3. Ror homolog nhr-23 is essential for both developmental clock and circadian clock in C. elegans. Hiroki S, et al. Commun Biol, 2024 Feb 28. PMID 38418700, Free PMC Article
  4. Expression and function of conserved nuclear receptor genes in Caenorhabditis elegans. Gissendanner CR, et al. Dev Biol, 2004 Feb 15. PMID 14738886
  5. Identifying evolutionarily conserved genes in the dietary restriction response using bioinformatics and subsequent testing in Caenorhabditis elegans. Ludewig AH, et al. Genes Nutr, 2014 Jan. PMID 24311442, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hormone-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Nuclear hormone receptor family member nhr-85
NP_001021667.1
  • Confirmed by transcript evidence
NP_001021668.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    13055201..13062122 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001026496.3 → NP_001021667.1  Nuclear hormone receptor family member nhr-85 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021667.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q6BER3, Q9XUK7
    Conserved Domains (2) summary
    cd07166
    Location:110 → 196
    NR_DBD_REV_ERB; DNA-binding domain of REV-ERB receptor-like is composed of two C4-type zinc fingers
    smart00430
    Location:261 → 369
    HOLI; Ligand binding domain of hormone receptors

  2. NM_001026497.4 → NP_001021668.1  Nuclear hormone receptor family member nhr-85 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021668.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9XUK7
    Conserved Domains (2) summary
    cl02596
    Location:1 → 18
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
    cl11397
    Location:83 → 191
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9XUK7.2

Gene LinkOut

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