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gcy-15 Receptor-type guanylate cyclase gcy-15 [ Caenorhabditis elegans ]

Gene ID: 191648, updated on 9-Dec-2024

Summary

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Official Symbol
gcy-15
Official Full Name
Receptor-type guanylate cyclase gcy-15
Primary source
WormBase:WBGene00001541
Locus tag
CELE_ZC239.7
See related
AllianceGenome:WB:WBGene00001541
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable guanylate cyclase activity and peptide receptor activity. Predicted to be involved in cGMP biosynthetic process and receptor guanylyl cyclase signaling pathway. Predicted to be active in plasma membrane. Is expressed in ASGL and ASGR. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See gcy-15 in Genome Data Viewer
Location:
chromosome: II
Exon count:
16
Sequence:
Chromosome: II; NC_003280.10 (3192349..3197066, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class I Neighboring gene Uncharacterized protein Neighboring gene Serpentine Receptor, class I Neighboring gene Serpentine Receptor, class T Neighboring gene Serpentine Receptor, class H

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Receptor-type guanylate cyclase is required for carbon dioxide sensation by Caenorhabditis elegans. Hallem EA, et al. Proc Natl Acad Sci U S A, 2011 Jan 4. PMID 21173231, Free PMC Article
  2. Invertebrates yield a plethora of atypical guanylyl cyclases. Morton DB. Mol Neurobiol, 2004 Apr. PMID 15126679
  3. Searching for neuronal left/right asymmetry: genomewide analysis of nematode receptor-type guanylyl cyclases. Ortiz CO, et al. Genetics, 2006 May. PMID 16547101, Free PMC Article
  4. The neural basis of heat seeking in a human-infective parasitic worm. Bryant AS, et al. Curr Biol, 2022 May 23. PMID 35483361, Free PMC Article
  5. Identification of guanylyl cyclases that function in thermosensory neurons of Caenorhabditis elegans. Inada H, et al. Genetics, 2006 Apr. PMID 16415369, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables guanylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanylate cyclase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cGMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cGMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cyclic nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in receptor guanylyl cyclase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Receptor-type guanylate cyclase gcy-15
NP_001364713.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    3192349..3197066 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001377748.2 → NP_001364713.1  Receptor-type guanylate cyclase gcy-15 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P91550
    Conserved Domains (4) summary
    cd13992
    Location:553 → 822
    PK_GC; Pseudokinase domain of membrane Guanylate Cyclase receptors
    pfam00211
    Location:885 → 1071
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam07701
    Location:831 → 879
    HNOBA; Heme NO binding associated
    cl10011
    Location:2 → 363
    Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
Nucleotide Protein
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