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Grin3a glutamate ionotropic receptor NMDA type subunit 3A [ Rattus norvegicus (Norway rat) ]

Gene ID: 191573, updated on 4-Jan-2025

Summary

Official Symbol
Grin3aprovided by RGD
Official Full Name
glutamate ionotropic receptor NMDA type subunit 3Aprovided by RGD
Primary source
RGD:621704
See related
EnsemblRapid:ENSRNOG00000005723 AllianceGenome:RGD:621704
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
NR3; chi-1; GluN3A
Summary
Enables carboxylic acid binding activity; glutamate-gated receptor activity; and protein phosphatase 2A binding activity. Contributes to NMDA glutamate receptor activity. Involved in several processes, including ionotropic glutamate receptor signaling pathway; monoatomic cation transport; and negative regulation of dendritic spine development. Located in cytoplasm and postsynaptic membrane. Part of NMDA selective glutamate receptor complex. Is active in glutamatergic synapse and postsynaptic density membrane. Orthologous to human GRIN3A (glutamate ionotropic receptor NMDA type subunit 3A). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Brain (RPKM 52.7), Muscle (RPKM 4.6) and 1 other tissue See more
Orthologs
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Genomic context

See Grin3a in Genome Data Viewer
Location:
5q22
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (68802333..69001880, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (64006847..64206408, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (64928620..65073012, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134478968 Neighboring gene eukaryotic translation initiation factor 2 subunit alpha, pseudogene 1 Neighboring gene post-GPI attachment to proteins GalNAc transferase 4 Neighboring gene ring finger protein 20 Neighboring gene protein phosphatase 3, regulatory subunit B, beta Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134478969

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to NMDA glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to NMDA glutamate receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables NMDA glutamate receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables NMDA glutamate receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables NMDA glutamate receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables NMDA glutamate receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
 
enables calcium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glutamate-gated receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glutamate-gated receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables glycine binding IDA
Inferred from Direct Assay
more info
PubMed 
enables glycine binding IEA
Inferred from Electronic Annotation
more info
 
enables glycine binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase 2A binding IDA
Inferred from Direct Assay
more info
PubMed 
enables serine binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transmitter-gated monoatomic ion channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
 
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in calcium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in dendrite development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within dendrite development ISO
Inferred from Sequence Orthology
more info
 
involved_in ionotropic glutamate receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ionotropic glutamate receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ionotropic glutamate receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in modulation of chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in monoatomic cation transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of dendritic spine development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neuron development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in prepulse inhibition IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within prepulse inhibition ISO
Inferred from Sequence Orthology
more info
 
involved_in presynaptic modulation of chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
involved_in presynaptic modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of postsynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of synaptic plasticity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to ethanol IEA
Inferred from Electronic Annotation
more info
 
involved_in response to ethanol ISO
Inferred from Sequence Orthology
more info
 
involved_in rhythmic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of NMDA selective glutamate receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of NMDA selective glutamate receptor complex IEA
Inferred from Electronic Annotation
more info
 
part_of NMDA selective glutamate receptor complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
part_of monoatomic ion channel complex ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
part_of neurotransmitter receptor complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
is_active_in postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in presynapse IEA
Inferred from Electronic Annotation
more info
 
located_in synapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
glutamate receptor ionotropic, NMDA 3A
Names
N-methyl-D-aspartate receptor subtype 3A
NMDAR-L
NMDAR-L1
NMDAR3A
NR3 chi-1
NR3A
glutamate [NMDA] receptor subunit 3A
glutamate receptor chi-1
glutamate receptor, ionotropic, N-methyl-D-aspartate 3A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198583.2NP_001185512.1  glutamate receptor ionotropic, NMDA 3A isoform 2 precursor

    See identical proteins and their annotated locations for NP_001185512.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    BI294379, U29873
    UniProtKB/TrEMBL
    A6KJD4
    Conserved Domains (4) summary
    cd06377
    Location:30497
    PBP1_iGluR_NMDA_NR3; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR3 subunit of NMDA receptor family
    cd13720
    Location:512908
    PBP2_iGluR_NMDA_Nr3; The ligand-binding domain of the NR3 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:676942
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:127469
    ANF_receptor; Receptor family ligand binding region
  2. NM_138546.2NP_612555.1  glutamate receptor ionotropic, NMDA 3A isoform 1 precursor

    See identical proteins and their annotated locations for NP_612555.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF073379, BI294379
    UniProtKB/Swiss-Prot
    O09098, O09155, Q62800, Q63268, Q9R1M7, Q9Z2H0
    UniProtKB/TrEMBL
    A6KJD3
    Conserved Domains (4) summary
    cd06377
    Location:30497
    PBP1_iGluR_NMDA_NR3; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR3 subunit of NMDA receptor family
    cd13720
    Location:512908
    PBP2_iGluR_NMDA_Nr3; The ligand-binding domain of the NR3 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:676942
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:127469
    ANF_receptor; Receptor family ligand binding region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    68802333..69001880 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109241.2XP_038965169.1  glutamate receptor ionotropic, NMDA 3A isoform X1

    Related
    ENSRNOP00000007957.7, ENSRNOT00000007957.8
    Conserved Domains (3) summary
    cd13720
    Location:512908
    PBP2_iGluR_NMDA_Nr3; The ligand-binding domain of the NR3 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cd06377
    Location:40496
    PBP1_iGluR_NMDA_NR3; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR3 subunit of NMDA receptor family
    pfam00060
    Location:676942
    Lig_chan; Ligand-gated ion channel