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ZK1240.8 RING-type domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 191542, updated on 4-Jan-2025

Summary

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Official Symbol
ZK1240.8
Official Full Name
RING-type domain-containing protein
Primary source
WormBase:WBGene00022872
Locus tag
CELE_ZK1240.8
See related
AllianceGenome:WB:WBGene00022872
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable zinc ion binding activity. Human ortholog(s) of this gene implicated in several diseases, including Henoch-Schoenlein purpura; Sweet syndrome; asthma; familial Mediterranean fever; and hematologic cancer (multiple). Orthologous to several human genes including BSPRY (B-box and SPRY domain containing); MEFV (MEFV innate immunity regulator, pyrin); and RNF39 (ring finger protein 39). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See ZK1240.8 in Genome Data Viewer
Location:
chromosome: II
Exon count:
6
Sequence:
Chromosome: II; NC_003280.10 (2326978..2329063, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene RING-type domain-containing protein Neighboring gene Secreted protein Neighboring gene RING-type domain-containing protein Neighboring gene RING-type domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RING-type domain-containing protein
NP_494242.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    2326978..2329063 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_061841.3 → NP_494242.1  RING-type domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_494242.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O16683
    Conserved Domains (3) summary
    cd00162
    Location:6 → 47
    RING_Ubox; modified RING-HC finger (C3HC3D-type) [structural motif]
    cl00034
    Location:86 → 135
    Bbox_SF; B-box-type zinc finger superfamily
    cl17238
    Location:3 → 48
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
Nucleotide Protein
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