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hlh-10 Helix-loop-helix protein 10 [ Caenorhabditis elegans ]

Gene ID: 191402, updated on 9-Dec-2024

Summary

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Official Symbol
hlh-10
Official Full Name
Helix-loop-helix protein 10
Primary source
WormBase:WBGene00001954
Locus tag
CELE_ZK682.4
See related
AllianceGenome:WB:WBGene00001954
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables protein heterodimerization activity and transcription corepressor activity. Involved in negative regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in neurons. Human ortholog(s) of this gene implicated in coronary artery disease and ventricular septal defect. Orthologous to human MSC (musculin) and TCF21 (transcription factor 21). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See hlh-10 in Genome Data Viewer
Location:
chromosome: V
Exon count:
4
Sequence:
Chromosome: V; NC_003283.11 (9280512..9282210, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Leucine-rich repeat-containing protein 15-like Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation and characterization of the activated B-cell factor 1 homolog in Caenorhabditis elegans. Nguyen L, et al. Nucleic Acids Res, 2001 Nov 1. PMID 11691930, Free PMC Article
  2. Cell-Autonomous and Non-Cell-Autonomous Regulation of a Feeding State-Dependent Chemoreceptor Gene via MEF-2 and bHLH Transcription Factors. Gruner M, et al. PLoS Genet, 2016 Aug. PMID 27487365, Free PMC Article
  3. Identification of C. elegans sensory ray genes using whole-genome expression profiling. Portman DS, et al. Dev Biol, 2004 Jun 15. PMID 15183729
  4. A multiparameter network reveals extensive divergence between C. elegans bHLH transcription factors. Grove CA, et al. Cell, 2009 Jul 23. PMID 19632181, Free PMC Article
  5. The molecular signature and cis-regulatory architecture of a C. elegans gustatory neuron. Etchberger JF, et al. Genes Dev, 2007 Jul 1. PMID 17606643, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in developmental process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Helix-loop-helix protein 10
NP_505401.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    9280512..9282210 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073000.4 → NP_505401.2  Helix-loop-helix protein 10 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505401.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q23579
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q23579.2

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