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hizr-1 High zinc activated nuclear receptor protein [ Caenorhabditis elegans ]

Gene ID: 191322, updated on 4-Jan-2025

Summary

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Official Symbol
hizr-1
Official Full Name
High zinc activated nuclear receptor protein
Primary source
WormBase:WBGene00013976
Locus tag
CELE_ZK455.6
See related
AllianceGenome:WB:WBGene00013976
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables DNA-binding transcription factor activity; cis-regulatory region sequence-specific DNA binding activity; and zinc ion binding activity. Involved in intracellular zinc ion homeostasis and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in head and intestine. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See hizr-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
13
Sequence:
Chromosome: X; NC_003284.9 (11318278..11321078)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Laminin N-terminal domain-containing protein Neighboring gene Neuropeptide-Like Protein Neighboring gene Sphingomyelin phosphodiesterase 2 Neighboring gene Nucleotide-diphospho-sugar transferase domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cadmium hijacks the high zinc response by binding and activating the HIZR-1 nuclear receptor. Earley BJ, et al. Proc Natl Acad Sci U S A, 2021 Oct 19. PMID 34649987, Free PMC Article
  2. The Nuclear Receptor HIZR-1 Uses Zinc as a Ligand to Mediate Homeostasis in Response to High Zinc. Warnhoff K, et al. PLoS Biol, 2017 Jan. PMID 28095401, Free PMC Article
  3. Mediator subunit MDT-15/MED15 and Nuclear Receptor HIZR-1/HNF4 cooperate to regulate toxic metal stress responses in Caenorhabditis elegans. Shomer N, et al. PLoS Genet, 2019 Dec. PMID 31815936, Free PMC Article
  4. A pathway for low zinc homeostasis that is conserved in animals and acts in parallel to the pathway for high zinc homeostasis. Dietrich N, et al. Nucleic Acids Res, 2017 Nov 16. PMID 28977437, Free PMC Article
  5. BLIMP-1/BLMP-1 and Metastasis-Associated Protein Regulate Stress Resistant Development in Caenorhabditis elegans. Hyun M, et al. Genetics, 2016 Aug. PMID 27334271, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cadmium hijacks the high zinc response by binding and activating the HIZR-1 nuclear receptor.
    Title: Cadmium hijacks the high zinc response by binding and activating the HIZR-1 nuclear receptor.
  2. Data show that mdt-15 and hizr-1 cooperate to regulate cadmium detoxification and zinc storage and that this mechanism is at least partially conserved in mammals.
    Title: Mediator subunit MDT-15/MED15 and Nuclear Receptor HIZR-1/HNF4 cooperate to regulate toxic metal stress responses in Caenorhabditis elegans.
  3. The essential micronutrient zinc acts as a HIZR-1 ligand, and activated HIZR-1 increases transcription of genes that promote zinc efflux and storage.
    Title: The Nuclear Receptor HIZR-1 Uses Zinc as a Ligand to Mediate Homeostasis in Response to High Zinc.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables cis-regulatory region sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular zinc ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
High zinc activated nuclear receptor protein
NP_509893.3
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    11318278..11321078
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077492.7 → NP_509893.3  High zinc activated nuclear receptor protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509893.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5ED47
    Conserved Domains (2) summary
    smart00399
    Location:13 → 82
    ZnF_C4; c4 zinc finger in nuclear hormone receptors
    smart00430
    Location:195 → 365
    HOLI; Ligand binding domain of hormone receptors
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5ED47.1

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