kri-1 FERM domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: kri-1
Official Full Name: FERM domain-containing protein
Primary source: WormBase:WBGene00013955
Locus tag: CELE_ZK265.1
See related: AllianceGenome:WB:WBGene00013955
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Involved in positive regulation of gene expression. Located in apical plasma membrane; apicolateral plasma membrane; and nucleus. Is expressed in intestine and pharynx. Used to study cerebral cavernous malformation. Human ortholog(s) of this gene implicated in cerebral cavernous malformation and cerebral cavernous malformation 1. Orthologous to human KRIT1 (KRIT1 ankyrin repeat containing). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See kri-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 15

Sequence:: Chromosome: I; NC_003279.8 (8226494..8240637, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study define the apoptotic pathway downstream of KRI-1 by conducting a forward genetic mutagenesis screen to restore ionizing radiation-induced apoptosis in kri-1 mutant worms. Proteomic analysis of KRI-1 binding partners identifies the previously uncharacterized protein K07A9.3, which is the ortholog of human CCM2 and a regulator of the ERK-5 pathway.
Title: A conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis.
Kri-1 is required to activate DNA damage-dependent cell death of germ cells independently of cep-1/p53.
Title: Cell-nonautonomous regulation of C. elegans germ cell death by kri-1.
Data show that the reproductive system communicates with the intestine through lipophilic-hormone signaling and that a gene called kri-1 is likely to act in the intestine to promote DAF-16 nuclear localization in response to this signal.
Title: Germ-cell loss extends C. elegans life span through regulation of DAF-16 by kri-1 and lipophilic-hormone signaling.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZK265.1 (e-PCR)
- UniSTS:310462

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Process	Evidence Code	Pubs
involved_in cell redox homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of establishment of cell polarity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apicolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: FERM domain-containing protein

NP_001021863.1

Confirmed by transcript evidence

NP_001021864.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

8226494..8240637 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001026692.6 → NP_001021863.1 FERM domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021863.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EDH0

Conserved Domains (6) summary

smart00295
Location:448 → 645

B41; Band 4.1 homologues

cd00204
Location:305 → 421

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:306 → 401

Ank_2; Ankyrin repeats (3 copies)

pfam16705
Location:126 → 210

NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT

sd00045
Location:305 → 332

ANK; ANK repeat [structural motif]

cl09511
Location:548 → 645

FERM_B-lobe; FERM domain B-lobe
NM_001026693.5 → NP_001021864.1 FERM domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021864.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EF18

Conserved Domains (6) summary

smart00295
Location:448 → 645

B41; Band 4.1 homologues

cd00204
Location:305 → 421

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:306 → 401

Ank_2; Ankyrin repeats (3 copies)

pfam16705
Location:126 → 210

NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT

sd00045
Location:305 → 332

ANK; ANK repeat [structural motif]

cl09511
Location:548 → 645

FERM_B-lobe; FERM domain B-lobe