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hsd-2 3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 191049, updated on 9-Dec-2024

Summary

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Official Symbol
hsd-2
Official Full Name
3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein
Primary source
WormBase:WBGene00022498
Locus tag
CELE_ZC8.1
See related
AllianceGenome:WB:WBGene00022498
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in steroid biosynthetic process. Predicted to be located in membrane. Is expressed in intestine. Human ortholog(s) of this gene implicated in CHILD syndrome and CK syndrome. Orthologous to several human genes including SDR42E2 (short chain dehydrogenase/reductase family 42E, member 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See hsd-2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
7
Sequence:
Chromosome: X; NC_003284.9 (5005240..5007037)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Phosphatidylinositol 4-kinase type 2 Neighboring gene Rootletin-like coiled-coil domain-containing protein Neighboring gene ncRNA Neighboring gene MYND-type domain-containing protein Neighboring gene 3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein Neighboring gene SCP domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Steroid hormone pathways coordinate developmental diapause and olfactory remodeling in Pristionchus pacificus. Carstensen HR, et al. Genetics, 2021 Jun 24. PMID 33963848, Free PMC Article
  2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables 3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein
NP_508851.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    5005240..5007037
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_076450.7 → NP_508851.1  3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_508851.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q23086
    Conserved Domains (1) summary
    cl21454
    Location:5 → 327
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein
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