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ncx-10 Sodium/calcium exchanger membrane region domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 190821, updated on 4-Jan-2025

Summary

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Official Symbol
ncx-10
Official Full Name
Sodium/calcium exchanger membrane region domain-containing protein
Primary source
WormBase:WBGene00003575
Locus tag
CELE_Y97E10B.7
See related
AllianceGenome:WB:WBGene00003575
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable calcium:sodium antiporter activity. Predicted to be involved in intracellular calcium ion homeostasis and monoatomic cation transport. Predicted to be active in membrane. Is expressed in pharyngeal muscle cell and terminal bulb. Orthologous to human SLC8B1 (solute carrier family 8 member B1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See ncx-10 in Genome Data Viewer
Location:
chromosome: V
Exon count:
10
Sequence:
Chromosome: V; NC_003283.11 (7930475..7933098, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Pan-phylum genome-wide identification of sodium calcium exchangers reveal heterogeneous expansions and possible roles in nematode parasitism. Bode K, et al. Gene, 2022 Feb 5. PMID 34756961
  2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium:sodium antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in calcium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic cation transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Sodium/calcium exchanger membrane region domain-containing protein
NP_001256094.1
  • Partially confirmed by transcript evidence
NP_001360010.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    7930475..7933098 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001373058.1 → NP_001360010.1  Sodium/calcium exchanger membrane region domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    D9P2J5
    Conserved Domains (2) summary
    PLN03151
    Location:5 → 454
    PLN03151; cation/calcium exchanger; Provisional
    pfam01699
    Location:375 → 542
    Na_Ca_ex; Sodium/calcium exchanger protein

  2. NM_001269165.1 → NP_001256094.1  Sodium/calcium exchanger membrane region domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256094.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q965R5
    Conserved Domains (2) summary
    PLN03151
    Location:35 → 571
    PLN03151; cation/calcium exchanger; Provisional
    pfam01699
    Location:492 → 659
    Na_Ca_ex; Sodium/calcium exchanger protein
Nucleotide Protein
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