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zfr-1 DZF domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 190806, updated on 9-Dec-2024

Summary

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Official Symbol
zfr-1
Official Full Name
DZF domain-containing protein
Primary source
WormBase:WBGene00022388
Locus tag
CELE_Y95B8A.8
See related
AllianceGenome:WB:WBGene00022388
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable double-stranded RNA binding activity and single-stranded RNA binding activity. Acts upstream of or within with a positive effect on axon guidance. Predicted to be part of spliceosomal complex. Orthologous to several human genes including ZFR (zinc finger RNA binding protein) and ZFR2 (zinc finger RNA binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See zfr-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
13
Sequence:
Chromosome: I; NC_003279.8 (853451..872827)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Sperm mitochondrial-associated cysteine-rich protein-like Neighboring gene Protein kinase domain-containing protein Neighboring gene ncRNA Neighboring gene Phosphodiesterase;putative 3',5'-cyclic phosphodiesterase pde-6 Neighboring gene Bursicon;Bursicon subunit alpha;Secreted protein Neighboring gene FBD domain-containing protein Neighboring gene Guanine nucleotide-binding protein alpha-16 subunit Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The zinc finger RNA binding protein, ZFR, contributes to axon guidance in Caenorhabditis elegans. Kjærgaard T, et al. Gene, 2015 Feb 15. PMID 25476027
  2. The ZFP-1(AF10)/DOT-1 complex opposes H2B ubiquitination to reduce Pol II transcription. Cecere G, et al. Mol Cell, 2013 Jun 27. PMID 23806335, Free PMC Article
  3. Axon guidance genes identified in a large-scale RNAi screen using the RNAi-hypersensitive Caenorhabditis elegans strain nre-1(hd20) lin-15b(hd126). Schmitz C, et al. Proc Natl Acad Sci U S A, 2007 Jan 16. PMID 17213328, Free PMC Article
  4. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article
  5. SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans. Robert VJ, et al. Development, 2023 Nov 1. PMID 37818613, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within_positive_effect axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within_positive_effect mRNA splicing, via spliceosome IC
Inferred by Curator
more info
  
acts_upstream_of_or_within_positive_effect neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of spliceosomal complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
DZF domain-containing protein
NP_490785.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    853451..872827
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058384.5 → NP_490785.3  DZF domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_490785.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    E9RKC7
    Conserved Domains (4) summary
    smart00572
    Location:481 → 720
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    smart00451
    Location:125 → 157
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:129 → 151
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:175 → 198
    zf-met; Zinc-finger of C2H2 type
Nucleotide Protein
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