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elc-1 Elongin-C [ Caenorhabditis elegans ]

Gene ID: 190775, updated on 9-Dec-2024

Summary

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Official Symbol
elc-1
Official Full Name
Elongin-C
Primary source
WormBase:WBGene00001236
Locus tag
CELE_Y82E9BR.15
See related
AllianceGenome:WB:WBGene00001236
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables protein domain specific binding activity and protein-macromolecule adaptor activity. Involved in anterior/posterior axis specification, embryo; positive regulation of metaphase/anaphase transition of meiotic cell cycle; and sister chromosome movement towards spindle pole involved in meiotic sister chromatid segregation. Part of Cul2-RING ubiquitin ligase complex. Is expressed in hypodermis; intestine; pharynx; and vulval muscle. Orthologous to human ELOC (elongin C). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See elc-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
2
Sequence:
Chromosome: III; NC_003281.10 (1414238..1417190, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ATP synthase subunit epsilon Neighboring gene Glycolipid transfer protein domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ATP synthase c subunit

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Correction: PRAME Is a Golgi-Targeted Protein That Associates with the Elongin BC Complex and Is Upregulated by Interferon-Gamma and Bacterial PAMPs. Wadelin FR, et al. PLoS One, 2015. PMID 26068868, Free PMC Article
  2. Inhibition of elongin C promotes longevity and protein homeostasis via HIF-1 in C. elegans. Hwang W, et al. Aging Cell, 2015 Dec. PMID 26361075, Free PMC Article
  3. Caenorhabditis elegans Elongin BC complex is essential for cell proliferation and chromosome condensation and segregation during mitosis and meiotic division II. Sasagawa Y, et al. Chromosome Res, 2005. PMID 15973501
  4. The elongin B ubiquitin homology domain. Identification of Elongin B sequences important for interaction with Elongin C. Brower CS, et al. J Biol Chem, 1999 May 7. PMID 10224134
  5. Caenorhabditis elegans p97 controls germline-specific sex determination by controlling the TRA-1 level in a CUL-2-dependent manner. Sasagawa Y, et al. J Cell Sci, 2009 Oct 15. PMID 19773360

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. knockdown of elc-1 prolonged lifespan and delayed paralysis caused by impaired protein homeostasis by upregulating HIF-1.
    Title: Inhibition of elongin C promotes longevity and protein homeostasis via HIF-1 in C. elegans.
  2. Elongin B (ELB1) and C (ELC1) form a stable complex, and that depletion of either gene product by RNA-mediated interference (RNAi) causes pronounced defects in the second meiotic division
    Title: Caenorhabditis elegans Elongin BC complex is essential for cell proliferation and chromosome condensation and segregation during mitosis and meiotic division II.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-macromolecule adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-macromolecule adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in anterior/posterior axis specification, embryo IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of metaphase/anaphase transition of meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sister chromosome movement towards spindle pole involved in meiotic sister chromatid segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Cul2-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Cul2-RING ubiquitin ligase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of elongin complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Elongin-C
NP_001380023.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    1414238..1417190 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001393280.1 → NP_001380023.1  Elongin-C [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9BKS1
    Conserved Domains (1) summary
    cd18321
    Location:30 → 124
    BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins
Nucleotide Protein
Heading Accession and Version

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