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Y47G6A.5 Tyrosine-protein kinase [ Caenorhabditis elegans ]

Gene ID: 189992, updated on 4-Jan-2025

Summary

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Official Symbol
Y47G6A.5
Official Full Name
Tyrosine-protein kinase
Primary source
WormBase:WBGene00021635
Locus tag
CELE_Y47G6A.5
See related
AllianceGenome:WB:WBGene00021635
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Predicted to be involved in cell differentiation and cell surface receptor protein tyrosine kinase signaling pathway. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See Y47G6A.5 in Genome Data Viewer
Location:
chromosome: I
Exon count:
12
Sequence:
Chromosome: I; NC_003279.8 (3533885..3539580)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Peptidase M14 carboxypeptidase A domain-containing protein;ShKT domain-containing protein Neighboring gene 40S ribosomal protein S19-binding protein 1 Neighboring gene ncRNA Neighboring gene Poly(U)-binding-splicing factor rnp-6 Neighboring gene RNA interference defective protein 10 Neighboring gene DeHydrogenases, Short chain Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A global analysis of genetic interactions in Caenorhabditis elegans. Byrne AB, et al. J Biol, 2007. PMID 17897480, Free PMC Article
  2. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article
  3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Tyrosine-protein kinase
NP_491175.2
  • Confirmed by transcript evidence
NP_871806.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    3533885..3539580
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058774.5 → NP_491175.2  Tyrosine-protein kinase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491175.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9N3S5
    Conserved Domains (4) summary
    smart00219
    Location:328 → 600
    TyrKc; Tyrosine kinase, catalytic domain
    cd00192
    Location:332 → 601
    PTKc; Catalytic domain of Protein Tyrosine Kinases
    cl15255
    Location:201 → 305
    SH2; Src homology 2 (SH2) domain
    cl17036
    Location:151 → 194
    SH3; Src Homology 3 domain superfamily

  2. NM_182006.5 → NP_871806.1  Tyrosine-protein kinase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_871806.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IAA6
    Conserved Domains (4) summary
    smart00219
    Location:284 → 556
    TyrKc; Tyrosine kinase, catalytic domain
    cd00192
    Location:288 → 557
    PTKc; Catalytic domain of Protein Tyrosine Kinases
    cl15255
    Location:157 → 261
    SH2; Src homology 2 (SH2) domain
    cl17036
    Location:107 → 150
    SH3; Src Homology 3 domain superfamily
Nucleotide Protein
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