afmd-2 Abhydrolase_3 domain-containing protein;Alpha/beta hydrolase fold-3 domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: afmd-2
Official Full Name: Abhydrolase_3 domain-containing protein;Alpha/beta hydrolase fold-3 domain-containing protein
Primary source: WormBase:WBGene00012866
Locus tag: CELE_Y45F10A.3
See related: AllianceGenome:WB:WBGene00012866
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable hydrolase activity. Predicted to be involved in tryptophan catabolic process to kynurenine. Predicted to be active in cytoplasm. Orthologous to human AFMID (arylformamidase). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See afmd-2 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 5

Sequence:: Chromosome: IV; NC_003282.8 (13509224..13513433)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

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Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y45F10A.3 (e-PCR)
- UniSTS:322414

Y45F10A.2 (e-PCR)
- UniSTS:311192

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in tryptophan catabolic process to kynurenine	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Abhydrolase_3 domain-containing protein;Alpha/beta hydrolase fold-3 domain-containing protein

NP_001293952.1

Confirmed by transcript evidence

NP_001293953.1

Confirmed by transcript evidence

NP_502605.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

13509224..13513433

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_070204.3 → NP_502605.2 Alpha/beta hydrolase fold-3 domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_502605.2

Status: REVIEWED

UniProtKB/TrEMBL

O62460

Conserved Domains (1) summary

COG0657
Location:26 → 173

Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
NM_001307023.3 → NP_001293952.1 Alpha/beta hydrolase fold-3 domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293952.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A061AJ76

Conserved Domains (1) summary

COG0657
Location:3 → 118

Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
NM_001307024.1 → NP_001293953.1 Abhydrolase_3 domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293953.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A061AKW2