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hex-3 beta-N-acetylhexosaminidase [ Caenorhabditis elegans ]

Gene ID: 189716, updated on 4-Jan-2025

Summary

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Official Symbol
hex-3
Official Full Name
beta-N-acetylhexosaminidase
Primary source
WormBase:WBGene00012663
Locus tag
CELE_Y39A1C.4
See related
AllianceGenome:WB:WBGene00012663
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables beta-N-acetylgalactosaminidase activity. Involved in polysaccharide metabolic process. Predicted to be located in membrane. Is expressed in intestine. Orthologous to human HEXD (hexosaminidase D). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See hex-3 in Genome Data Viewer
Location:
chromosome: III
Exon count:
5
Sequence:
Chromosome: III; NC_003281.10 (10849222..10855924)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Endonuclease/exonuclease/phosphatase domain-containing protein Neighboring gene F-box domain-containing protein Neighboring gene Transmembrane inner ear Neighboring gene HECT domain-containing protein Neighboring gene CSD domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Galactosylated fucose epitopes in nematodes: increased expression in a Caenorhabditis mutant associated with altered lectin sensitivity and occurrence in parasitic species. Yan S, et al. J Biol Chem, 2012 Aug 17. PMID 22733825, Free PMC Article
  2. Enzymatic properties and subtle differences in the substrate specificity of phylogenetically distinct invertebrate N-glycan processing hexosaminidases. Dragosits M, et al. Glycobiology, 2015 Apr. PMID 25488985, Free PMC Article
  3. N-glycan antennal modifications are altered in Caenorhabditis elegans lacking the HEX-4 N-acetylgalactosamine-specific hexosaminidase. Paschinger K, et al. J Biol Chem, 2023 Apr. PMID 36813232, Free PMC Article
  4. Biosynthesis of truncated N-linked oligosaccharides results from non-orthologous hexosaminidase-mediated mechanisms in nematodes, plants, and insects. Gutternigg M, et al. J Biol Chem, 2007 Sep 21. PMID 17636254, Free PMC Article
  5. Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans. Sun Y, et al. Elife, 2020 Jun 2. PMID 32482227, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables beta-N-acetylgalactosaminidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables beta-N-acetylhexosaminidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hexosaminidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hexosaminidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hexosaminidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in polysaccharide metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
beta-N-acetylhexosaminidase
NP_499390.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    10849222..10855924
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066989.6 → NP_499390.3  beta-N-acetylhexosaminidase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499390.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    A7DY67, G5EDG9
    Conserved Domains (1) summary
    cd06565
    Location:112 → 425
    GH20_GcnA-like; Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine ...
Nucleotide Protein
Heading Accession and Version

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