Y38E10A.8 Protein kinase domain-containing protein [Caenorhabditis elegans] - Gene

Summary

Official Symbol: Y38E10A.8
Official Full Name: Protein kinase domain-containing protein
Primary source: WormBase:WBGene00012586
Locus tag: CELE_Y38E10A.8
See related: AllianceGenome:WB:WBGene00012586
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable eukaryotic translation initiation factor 2alpha kinase activity. Predicted to be involved in negative regulation of translation and regulation of translational initiation. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Wolcott-Rallison syndrome; dystonia 33; hepatitis B; neurodegenerative disease (multiple); and type 1 diabetes mellitus. Orthologous to human EIF2AK2 (eukaryotic translation initiation factor 2 alpha kinase 2) and EIF2AK3 (eukaryotic translation initiation factor 2 alpha kinase 3). [provided by Alliance of Genome Resources, Jan 2025]
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Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

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Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of translational initiation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

NP_496691.3

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