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tor-1 Torsin [ Caenorhabditis elegans ]

Gene ID: 189605, updated on 9-Dec-2024

Summary

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Official Symbol
tor-1
Official Full Name
Torsin
Primary source
WormBase:WBGene00006597
Locus tag
CELE_Y37A1B.12
See related
AllianceGenome:WB:WBGene00006597
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ATP binding activity and ATP hydrolysis activity. Predicted to be involved in cellular response to misfolded protein. Predicted to be located in endoplasmic reticulum lumen. Is expressed in anal depressor muscle; head mesodermal cell; head neurons; and intestinal muscle. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita-5 and torsion dystonia 1. Orthologous to several human genes including TOR1A (torsin family 1 member A) and TOR1B (torsin family 1 member B). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See tor-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
3
Sequence:
Chromosome: IV; NC_003282.8 (13984202..13985805, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Torsin Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An animal model to discern torsin function: suppression of protein aggregation in C. elegans. Caldwell GA, et al. Adv Neurol, 2004. PMID 14509658
  2. Suppression of polyglutamine-induced protein aggregation in Caenorhabditis elegans by torsin proteins. Caldwell GA, et al. Hum Mol Genet, 2003 Feb 1. PMID 12554684
  3. The Caenorhabditis elegans polarity gene ooc-5 encodes a Torsin-related protein of the AAA ATPase superfamily. Basham SE, et al. Development, 2001 Nov. PMID 11714689
  4. Longevity genes: from primitive organisms to humans. Warner HR. Mech Ageing Dev, 2005 Feb. PMID 15621202
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to misfolded protein IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chaperone cofactor-dependent protein refolding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Torsin
NP_001369805.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    13984202..13985805 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001383240.1 → NP_001369805.1  Torsin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    O45271
    Conserved Domains (2) summary
    COG0542
    Location:13 → 250
    ClpA; ATP-dependent Clp protease ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones]
    pfam06309
    Location:12 → 130
    Torsin
Nucleotide Protein
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