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sqst-4 ZZ-type domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 189561, updated on 9-Dec-2024

Summary

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Official Symbol
sqst-4
Official Full Name
ZZ-type domain-containing protein
Primary source
WormBase:WBGene00012516
Locus tag
CELE_Y32B12A.1
See related
AllianceGenome:WB:WBGene00012516
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity and protein kinase C binding activity. Predicted to be involved in aggrephagy; endosome organization; and mitophagy. Predicted to be located in cytoplasm and nucleus. Predicted to be active in aggresome and amphisome. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See sqst-4 in Genome Data Viewer
Location:
chromosome: V
Exon count:
2
Sequence:
Chromosome: V; NC_003283.11 (16488472..16489104)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene HYPK_UBA domain-containing protein Neighboring gene pseudo Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Natural variation in the sequestosome-related gene, sqst-5, underlies zinc homeostasis in Caenorhabditis elegans. Evans KS, et al. PLoS Genet, 2020 Nov. PMID 33175833, Free PMC Article
  2. Molecular definitions of autophagy and related processes. Galluzzi L, et al. EMBO J, 2017 Jul 3. PMID 28596378, Free PMC Article
  3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables K63-linked polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase C binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in aggrephagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endosome organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in aggresome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in amphisome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ZZ-type domain-containing protein
NP_507173.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    16488472..16489104
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_074772.2 → NP_507173.1  ZZ-type domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_507173.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XXG8
    Conserved Domains (1) summary
    cd02340
    Location:133 → 175
    ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
Nucleotide Protein
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