W02F12.2 Alkaline ceramidase [Caenorhabditis elegans] - Gene

Summary

Official Symbol: W02F12.2
Official Full Name: Alkaline ceramidase
Primary source: WormBase:WBGene00020947
Locus tag: CELE_W02F12.2
See related: AllianceGenome:WB:WBGene00020947
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable N-acylsphingosine amidohydrolase activity. Predicted to be involved in ceramide catabolic process and sphingosine biosynthetic process. Predicted to be located in Golgi membrane. Orthologous to several human genes including ACER1 (alkaline ceramidase 1). [provided by Alliance of Genome Resources, Jan 2025]
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Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

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Function	Evidence Code	Pubs
enables N-acylsphingosine amidohydrolase activity	IEA Inferred from Electronic Annotation more info
enables N-acylsphingosine amidohydrolase activity	ISS Inferred from Sequence or Structural Similarity more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ceramide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ceramide metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in sphingolipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in sphingosine biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info

NP_001370798.1

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