clec-38 C-type lectin domain-containing protein 38 [Caenorhabditis elegans] - Gene

Summary

Official Symbol: clec-38
Official Full Name: C-type lectin domain-containing protein 38
Primary source: WormBase:WBGene00012025
Locus tag: CELE_T25E12.10
See related: AllianceGenome:WB:WBGene00012025
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable carbohydrate binding activity. Involved in several processes, including axon guidance; regulation of neuron projection development; and synaptic vesicle localization. Predicted to be located in membrane. Is expressed in PLML; PLMR; head neurons; intestine; and ventral cord neurons. [provided by Alliance of Genome Resources, Nov 2024]
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Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

CLEC-38 plays a role in promoting synapse assembly and refining axon outgrowth activity.
Title: CLEC-38, a transmembrane protein with C-type lectin-like domains, negatively regulates UNC-40-mediated axon outgrowth and promotes presynaptic development in Caenorhabditis elegans.

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Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in dorsal/ventral axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in motor neuron axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of axon extension involved in axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of axon extension involved in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of collateral sprouting	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of sensory neuron axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of sensory neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of dorsal/ventral axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of motor neuron axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of sensory neuron axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sensory neuron axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in synaptic vesicle localization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

NP_507233.2

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