U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

npr-12 G-protein coupled receptors family 1 profile domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 188742, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
npr-12
Official Full Name
G-protein coupled receptors family 1 profile domain-containing protein
Primary source
WormBase:WBGene00020689
Locus tag
CELE_T22D1.12
See related
AllianceGenome:WB:WBGene00020689
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable neuropeptide Y receptor activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to be located in membrane. Is expressed in neurons. Human ortholog(s) of this gene implicated in amphetamine abuse; cocaine abuse; heroin dependence; nicotine dependence; and opiate dependence. Orthologous to human NPY1R (neuropeptide Y receptor Y1); NPY4R (neuropeptide Y receptor Y4); and NPY4R2 (neuropeptide Y receptor Y4-2). [provided by Alliance of Genome Resources, Dec 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See npr-12 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
8
Sequence:
Chromosome: IV; NC_003282.8 (6928928..6937648, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Carboxylesterase type B domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. An Antimicrobial Peptide and Its Neuronal Receptor Regulate Dendrite Degeneration in Aging and Infection. E L, et al. Neuron, 2018 Jan 3. PMID 29301098, Free PMC Article
  2. Induction of Protective Response Associated with Expressional Alterations in Neuronal G Protein-Coupled Receptors in Polystyrene Nanoparticle Exposed Caenorhabditis elegans. Yang Y, et al. Chem Res Toxicol, 2021 May 17. PMID 33650869
  3. Mass Spectrometry-Driven Discovery of Neuropeptides Mediating Nictation Behavior of Nematodes. Cockx B, et al. Mol Cell Proteomics, 2023 Feb. PMID 36481452, Free PMC Article
  4. Innate Immunity Promotes Sleep through Epidermal Antimicrobial Peptides. Sinner MP, et al. Curr Biol, 2021 Feb 8. PMID 33259791
  5. Molecular Basis of Neuronal Autophagy in Ageing: Insights from Caenorhabditis elegans. Konstantinidis G, et al. Cells, 2021 Mar 21. PMID 33800981, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables neuropeptide Y receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
G-protein coupled receptors family 1 profile domain-containing protein
NP_001293732.1
  • Confirmed by transcript evidence
NP_501071.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    6928928..6937648 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068670.2 → NP_501071.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501071.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9GZG8
    Conserved Domains (1) summary
    cd15203
    Location:36 → 337
    7tmA_NPYR-like; neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001306803.3 → NP_001293732.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293732.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CLI1
    Conserved Domains (1) summary
    cd15203
    Location:42 → 343
    7tmA_NPYR-like; neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools