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ceh-54 Homeobox domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 188474, updated on 4-Jan-2025

Summary

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Official Symbol
ceh-54
Official Full Name
Homeobox domain-containing protein
Primary source
WormBase:WBGene00020485
Locus tag
CELE_T13C5.4
See related
AllianceGenome:WB:WBGene00020485
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in neurons. Orthologous to several human genes including ESX1 (ESX homeobox 1); RHOXF1 (Rhox homeobox family member 1); and RHOXF2 (Rhox homeobox family member 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See ceh-54 in Genome Data Viewer
Location:
chromosome: X
Exon count:
4
Sequence:
Chromosome: X; NC_003284.9 (6191605..6194241, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene DUF281 domain-containing protein Neighboring gene Secreted protein Neighboring gene 3-ketosteroid oxygenase;Cytochrome P450 Neighboring gene Beta carbonic anhydrase 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of the Doublesex/MAB-3 transcription factor DMD-9 in Caenorhabditis elegans. Godini R, et al. G3 (Bethesda), 2023 Feb 9. PMID 36454093, Free PMC Article
  2. Unique homeobox codes delineate all the neuron classes of C. elegans. Reilly MB, et al. Nature, 2020 Aug. PMID 32814896, Free PMC Article
  3. A 4D single-cell protein atlas of transcription factors delineates spatiotemporal patterning during embryogenesis. Ma X, et al. Nat Methods, 2021 Aug. PMID 34312566
  4. Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network. Reece-Hoyes JS, et al. Mol Cell, 2013 Jul 11. PMID 23791784, Free PMC Article
  5. Transcriptional regulation. Okkema PG, et al. WormBook, 2005 Dec 23. PMID 18050428, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Homeobox domain-containing protein
NP_001338798.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    6191605..6194241 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001351883.3 → NP_001338798.1  Homeobox domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q22459
    Conserved Domains (1) summary
    pfam00046
    Location:49 → 102
    Homeobox; Homeobox domain
Nucleotide Protein
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