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nas-21 Zinc metalloproteinase-like protein nas-21 [ Caenorhabditis elegans ]

Gene ID: 188422, updated on 2-Nov-2024

Summary

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Official Symbol
nas-21
Official Full Name
Zinc metalloproteinase-like protein nas-21
Primary source
WormBase:WBGene00003540
Locus tag
CELE_T11F9.5
See related
AllianceGenome:WB:WBGene00003540
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable metalloendopeptidase activity. Predicted to be involved in molting cycle and proteolysis. Predicted to be located in extracellular region. Is expressed in gonad; hyp7 syncytium; and intestine. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nas-21 in Genome Data Viewer
Location:
chromosome: V
Exon count:
5
Sequence:
Chromosome: V; NC_003283.11 (11472564..11473899)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Amino acid transporter protein 6 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Zinc metalloproteinase nas-20 Neighboring gene ncRNA Neighboring gene Zinc metalloproteinase nas-22 Neighboring gene YkgJ family cysteine cluster protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of the astacin family of metalloproteases in C. elegans. Park JO, et al. BMC Dev Biol, 2010 Jan 28. PMID 20109220, Free PMC Article
  2. The astacin protein family in Caenorhabditis elegans. Möhrlen F, et al. Eur J Biochem, 2003 Dec. PMID 14653817
  3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in molting cycle, collagen and cuticulin-based cuticle IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Zinc metalloproteinase-like protein nas-21
NP_505907.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    11472564..11473899
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073506.6 → NP_505907.2  Zinc metalloproteinase-like protein nas-21 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505907.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q22401, Q7Z0M8
    Conserved Domains (2) summary
    smart00235
    Location:52 → 192
    ZnMc; Zinc-dependent metalloprotease
    cd04280
    Location:59 → 231
    ZnMc_astacin_like; Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q22401.3

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