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Prl7d1 prolactin family 7, subfamily d, member 1 [ Mus musculus (house mouse) ]

Gene ID: 18814, updated on 27-Nov-2024

Summary

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Official Symbol
Prl7d1provided by MGI
Official Full Name
prolactin family 7, subfamily d, member 1provided by MGI
Primary source
MGI:MGI:97619
See related
Ensembl:ENSMUSG00000021348 AllianceGenome:MGI:97619
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PRP; Plfr; Ghd19; PLF-RP
Summary
Enables cytokine activity and hormone activity. Acts upstream of or within negative regulation of angiogenesis; negative regulation of blood vessel endothelial cell migration; and placenta blood vessel development. Located in extracellular space. Is expressed in ectoplacental cone; extraembryonic component; placenta; and trophoblast giant cell. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward placenta adult (RPKM 932.3) See more
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Genomic context

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See Prl7d1 in Genome Data Viewer
Location:
13 A3.1; 13 12.6 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (27892981..27900720, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (27708998..27716737, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene prolactin family 7, subfamily a, member 2 Neighboring gene prolactin pseudogene Neighboring gene STARR-seq mESC enhancer starr_34017 Neighboring gene STARR-seq mESC enhancer starr_34018 Neighboring gene prolactin family 7, subfamily c, member 1 Neighboring gene prolactin family 2, subfamily a, member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of proliferin-related protein. Colosi P, et al. Mol Endocrinol, 1988 Jun. PMID 3047555
  2. Overexpression of PRL7D1 in Leydig Cells Causes Male Reproductive Dysfunction in Mice. Liu Y, et al. Int J Mol Sci, 2016 Jan 13. PMID 26771609, Free PMC Article
  3. A new member of the prolactin-growth hormone gene family expressed in mouse placenta. Linzer DI, et al. EMBO J, 1985 Jun. PMID 4029117, Free PMC Article
  4. Proliferin-related protein overexpression in SGC‑7901 gastric cancer cells inhibits in vitro cell growth and tumorigenesis in nude mice. He M, et al. Oncol Rep, 2013 Jun. PMID 23589131
  5. Stimulation and inhibition of angiogenesis by placental proliferin and proliferin-related protein. Jackson D, et al. Science, 1994 Dec 2. PMID 7527157

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Together, this study demonstrates that Prl7d1 possesses antiangiogenic properties in deciduas and inhibits the development of junctional zone, which potentially alters the functional capacity of the placenta to support optimal fetal growth.
    Title: Deletion of Prl7d1 causes placental defects at mid-pregnancy in mice.
  2. PRL7D1 overexpression could lead to increased germ cell apoptosis and exert an inhibitory effect on testosterone production in Leydig cells by reducing the expression of certain steroidogenic-related genes.
    Title: Overexpression of PRL7D1 in Leydig Cells Causes Male Reproductive Dysfunction in Mice.
  3. Expression of PRP inhibits gastric carcinoma cell proliferation, motility, and tumorigenicity in vivo.
    Title: Proliferin-related protein overexpression in SGC‑7901 gastric cancer cells inhibits in vitro cell growth and tumorigenesis in nude mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Clone Names

  • MGC117676

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hormone activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables prolactin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of blood vessel endothelial cell migration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in female pregnancy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mammary gland development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of angiogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of blood vessel endothelial cell migration IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within placenta blood vessel development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within placenta development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of lactation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of receptor signaling pathway via JAK-STAT IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to nutrient levels IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
prolactin-7D1
Names
growth hormone d19
proliferin-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360090.1 → NP_001347019.1  prolactin-7D1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AL627326, AL732408
    Consensus CDS
    CCDS88432.1
    UniProtKB/TrEMBL
    Q9DAY8
    Related
    ENSMUSP00000021776.4, ENSMUST00000021776.4
    Conserved Domains (1) summary
    pfam00103
    Location:16 → 239
    Hormone_1; Somatotropin hormone family

  2. NM_011120.2 → NP_035250.1  prolactin-7D1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_035250.1

    Status: VALIDATED

    Source sequence(s)
    AK005421, X02594
    Consensus CDS
    CCDS26405.1
    UniProtKB/Swiss-Prot
    P04769
    UniProtKB/TrEMBL
    Q5SVM4
    Related
    ENSMUSP00000153033.2, ENSMUST00000224026.2
    Conserved Domains (1) summary
    cd10288
    Location:43 → 240
    prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    27892981..27900720 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P04769.1 GenPept UniProtKB/Swiss-Prot:P04769

Gene LinkOut

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