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mbr-1 Mblk-1-related factor 1 [ Caenorhabditis elegans ]

Gene ID: 187937, updated on 4-Jan-2025

Summary

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Official Symbol
mbr-1
Official Full Name
Mblk-1-related factor 1
Primary source
WormBase:WBGene00011315
Locus tag
CELE_T01C1.2
See related
AllianceGenome:WB:WBGene00011315
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including AUA; intestine; nerve ring neurons; tail; and vulva. Orthologous to human LCOR (ligand dependent nuclear receptor corepressor) and LCORL (ligand dependent nuclear receptor corepressor like). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See mbr-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
9
Sequence:
Chromosome: X; NC_003284.9 (10719548..10722054, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Ovule protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A trophic role for Wnt-Ror kinase signaling during developmental pruning in Caenorhabditis elegans. Hayashi Y, et al. Nat Neurosci, 2009 Aug. PMID 19561603
  2. A regulatory cascade of three transcription factors in a single specific neuron, DVC, in Caenorhabditis elegans. Feng H, et al. Gene, 2012 Feb 15. PMID 22207033, Free PMC Article
  3. MBR-1, a novel helix-turn-helix transcription factor, is required for pruning excessive neurites in Caenorhabditis elegans. Kage E, et al. Curr Biol, 2005 Sep 6. PMID 16139210
  4. Genome-wide functional analysis of CREB/long-term memory-dependent transcription reveals distinct basal and memory gene expression programs. Lakhina V, et al. Neuron, 2015 Jan 21. PMID 25611510, Free PMC Article
  5. A transcriptional cofactor regulatory network for the C. elegans intestine. Horowitz BB, et al. G3 (Bethesda), 2023 Jul 5. PMID 37119809, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MBR-1, a helix-turn-helix transcription factor, is required for pruning excessive neurites during larval stages.
    Title: MBR-1, a novel helix-turn-helix transcription factor, is required for pruning excessive neurites in Caenorhabditis elegans.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mblk-1-related factor 1
NP_509794.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    10719548..10722054 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077393.8 → NP_509794.2  Mblk-1-related factor 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509794.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EGQ5
    Conserved Domains (1) summary
    pfam05225
    Location:347 → 388
    HTH_psq; helix-turn-helix, Psq domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5EGQ5.1

Gene LinkOut

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