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aakg-4 CBS domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 187928, updated on 9-Dec-2024

Summary

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Official Symbol
aakg-4
Official Full Name
CBS domain-containing protein
Primary source
WormBase:WBGene00020135
Locus tag
CELE_T01B6.3
See related
AllianceGenome:WB:WBGene00020135
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable AMP binding activity; protein kinase binding activity; and protein kinase regulator activity. Predicted to be involved in cellular response to glucose starvation; regulation of carbohydrate metabolic process; and regulation of carbon utilization. Predicted to be part of nucleotide-activated protein kinase complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including accessory cell; dorsal nerve cord; neurons; non-striated muscle; and rectal epithelium. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See aakg-4 in Genome Data Viewer
Location:
chromosome: X
Exon count:
11
Sequence:
Chromosome: X; NC_003284.9 (2314894..2319338, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Sulfhydryl oxidase Neighboring gene ncRNA Neighboring gene Unconventional myosin heavy chain 6 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans. Tullet JM, et al. PLoS Genet, 2014 Feb. PMID 24516399, Free PMC Article
  2. C. elegans monitor energy status via the AMPK pathway to trigger innate immune responses against bacterial pathogens. Ju S, et al. Commun Biol, 2022 Jun 30. PMID 35773333, Free PMC Article
  3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables AMP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular response to glucose starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of gluconeogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of carbon utilization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nucleotide-activated protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
CBS domain-containing protein
NP_741725.2
  • Confirmed by transcript evidence
NP_741726.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    2314894..2319338 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171633.7 → NP_741726.2  CBS domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741726.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MPT4
    Conserved Domains (1) summary
    cd02205
    Location:6 → 120
    CBS_pair; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

  2. NM_171632.4 → NP_741725.2  CBS domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741725.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2L0K0
    Conserved Domains (3) summary
    COG0517
    Location:318 → 436
    CBS; CBS domain [Signal transduction mechanisms]
    cd02205
    Location:319 → 438
    CBS_pair; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cd04618
    Location:163 → 288
    CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
Nucleotide Protein
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