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smcr-8 Guanine nucleotide exchange protein smcr-8 [ Caenorhabditis elegans ]

Gene ID: 187901, updated on 4-Jan-2025

Summary

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Official Symbol
smcr-8
Official Full Name
Guanine nucleotide exchange protein smcr-8
Primary source
WormBase:WBGene00020095
Locus tag
CELE_R144.5
See related
AllianceGenome:WB:WBGene00020095
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in autophagy. Predicted to be located in cytoplasm. Predicted to be part of guanyl-nucleotide exchange factor complex. Orthologous to human SMCR8 (SMCR8-C9orf72 complex subunit). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See smcr-8 in Genome Data Viewer
Location:
chromosome: III
Exon count:
8
Sequence:
Chromosome: III; NC_003281.10 (4999375..5001368)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene PCI domain-containing protein 2 homolog Neighboring gene WD Repeat protein Neighboring gene Transmembrane protein 131 homolog Neighboring gene Coiled-coil domain-containing protein 25 Neighboring gene Transmembrane protein 144 homolog Neighboring gene ncRNA Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A C9orf72 ALS/FTD Ortholog Acts in Endolysosomal Degradation and Lysosomal Homeostasis. Corrionero A, et al. Curr Biol, 2018 May 21. PMID 29731301
  2. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of guanyl-nucleotide exchange factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Guanine nucleotide exchange protein smcr-8
NP_498060.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    4999375..5001368
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065659.6 → NP_498060.2  Guanine nucleotide exchange protein smcr-8 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498060.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09346
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q09346.2

Gene LinkOut

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