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R08F11.1 Glycosyl-hydrolase family 116 catalytic region domain-containing protein;Non-lysosomal glucosylceramidase [ Caenorhabditis elegans ]

Gene ID: 187703, updated on 4-Jan-2025

Summary

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Official Symbol
R08F11.1
Official Full Name
Glycosyl-hydrolase family 116 catalytic region domain-containing protein;Non-lysosomal glucosylceramidase
Primary source
WormBase:WBGene00019965
Locus tag
CELE_R08F11.1
See related
AllianceGenome:WB:WBGene00019965
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable beta-glucosidase activity. Predicted to be involved in carbohydrate metabolic process and glucosylceramide catabolic process. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 46. Orthologous to human GBA2 (glucosylceramidase beta 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See R08F11.1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
13
Sequence:
Chromosome: V; NC_003283.11 (3777297..3784217, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Dauer Up-Regulated Neighboring gene Methyltransferase domain-containing protein Neighboring gene Methyltransferase domain-containing protein Neighboring gene Cysteine synthase 3 Neighboring gene Peroxidase Neighboring gene pseudo Neighboring gene Serpentine Receptor, class T

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables beta-glucosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucosylceramidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glucosylceramide catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Glycosyl-hydrolase family 116 catalytic region domain-containing protein;Non-lysosomal glucosylceramidase
NP_001317760.1
  • Confirmed by transcript evidence
NP_001317833.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    3777297..3784217 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001330810.5 → NP_001317760.1  Non-lysosomal glucosylceramidase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    O01893

  2. NM_001330811.3 → NP_001317833.1  Glycosyl-hydrolase family 116 catalytic region domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A168H9S8
    Conserved Domains (1) summary
    pfam04685
    Location:3 → 319
    DUF608; Glycosyl-hydrolase family 116, catalytic region
Nucleotide Protein
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