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gpx-7 Glutathione peroxidase [ Caenorhabditis elegans ]

Gene ID: 187542, updated on 2-Nov-2024

Summary

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Official Symbol
gpx-7
Official Full Name
Glutathione peroxidase
Primary source
WormBase:WBGene00019846
Locus tag
CELE_R03G5.5
See related
AllianceGenome:WB:WBGene00019846
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable peroxidase activity. Predicted to be involved in cellular oxidant detoxification and response to oxidative stress. Located in cytosol. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma; colorectal cancer; and spondylometaphyseal dysplasia Sedaghatian type. Orthologous to human GPX4 (glutathione peroxidase 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See gpx-7 in Genome Data Viewer
Location:
chromosome: X
Exon count:
3
Sequence:
Chromosome: X; NC_003284.9 (7798949..7799780, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene tRNA-Gly Neighboring gene Disintegrin and metalloproteinase domain-containing protein 17 homolog Neighboring gene pseudo Neighboring gene 2TM domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ginkgo seed extract promotes longevity and stress resistance of Caenorhabditis elegans. Shen N, et al. Food Funct, 2021 Dec 13. PMID 34812833
  2. Deletion of the four phospholipid hydroperoxide glutathione peroxidase genes accelerates aging in Caenorhabditis elegans. Sakamoto T, et al. Genes Cells, 2014 Oct. PMID 25200408
  3. Mitochondrial thioredoxin system is required for enhanced stress resistance and extended longevity in long-lived mitochondrial mutants. Harris-Gauthier N, et al. Redox Biol, 2022 Jul. PMID 35598379, Free PMC Article
  4. Specific collagens maintain the cuticle permeability barrier in Caenorhabditis elegans. Sandhu A, et al. Genetics, 2021 Mar 31. PMID 33789349, Free PMC Article
  5. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peroxidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
  
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Glutathione peroxidase
NP_001123171.1
  • Partially confirmed by transcript evidence
NP_001359951.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    7798949..7799780 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001373375.2 → NP_001359951.1  Glutathione peroxidase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8WFK7
    Conserved Domains (1) summary
    cl00388
    Location:32 → 105
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

  2. NM_001129699.5 → NP_001123171.1  Glutathione peroxidase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001123171.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8WFK6
    Conserved Domains (1) summary
    cd00340
    Location:32 → 188
    GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...
Nucleotide Protein
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