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inpp-4B PH domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 187517, updated on 4-Jan-2025

Summary

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Official Symbol
inpp-4B
Official Full Name
PH domain-containing protein
Primary source
WormBase:WBGene00010975
Locus tag
CELE_R01H10.7
See related
AllianceGenome:WB:WBGene00010975
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity. Predicted to be involved in phosphatidylinositol-3-phosphate biosynthetic process. Predicted to be active in cytoplasm. Orthologous to several human genes including INPP4B (inositol polyphosphate-4-phosphatase type II B). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See inpp-4B in Genome Data Viewer
Location:
chromosome: III
Exon count:
9
Sequence:
Chromosome: III; NC_003281.10 (10261763..10266877, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Coronin-like protein cor-1 Neighboring gene Uncharacterized protein Neighboring gene RFS-1 Interacting Partner Neighboring gene BBSome complex member bbs-5 Neighboring gene Connector enhancer of kinase suppressor of ras Neighboring gene GDP-fucose protein O-fucosyltransferase 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. PtdIns(4,5)P₂ and PtdIns3P coordinate to regulate phagosomal sealing for apoptotic cell clearance. Cheng S, et al. J Cell Biol, 2015 Aug 3. PMID 26240185, Free PMC Article
  2. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in phosphatidylinositol-3-phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
PH domain-containing protein
NP_001366686.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    10261763..10266877 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001379887.2 → NP_001366686.1  PH domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q21623, Q8MUM1
    Conserved Domains (1) summary
    smart00233
    Location:41 → 118
    PH; Pleckstrin homology domain
Nucleotide Protein
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