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galt-1 Beta-1,4-galactosyltransferase galt-1 [ Caenorhabditis elegans ]

Gene ID: 187430, updated on 4-Jan-2025

Summary

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Official Symbol
galt-1
Official Full Name
Beta-1,4-galactosyltransferase galt-1
Primary source
WormBase:WBGene00019763
Locus tag
CELE_M03F8.4
See related
AllianceGenome:WB:WBGene00019763
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity. Involved in N-glycan processing and protein galactosylation. Predicted to be located in Golgi cisterna membrane. Predicted to be active in cytoplasm. Is expressed in coelomocyte and intestine. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See galt-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
8
Sequence:
Chromosome: V; NC_003283.11 (5930905..5933435)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Glycosyltransferase family 92 protein Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene TPR_REGION domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Array-assisted characterization of a fucosyltransferase required for the biosynthesis of complex core modifications of nematode N-glycans. Yan 闫石 S, et al. J Biol Chem, 2013 Jul 19. PMID 23754284, Free PMC Article
  2. Caenorhabditis elegans galectins LEC-6 and LEC-10 interact with similar glycoconjugates in the intestine. Maduzia LL, et al. J Biol Chem, 2011 Feb 11. PMID 21115491, Free PMC Article
  3. Caenorhabditis elegans N-glycan core beta-galactoside confers sensitivity towards nematotoxic fungal galectin CGL2. Butschi A, et al. PLoS Pathog, 2010 Jan. PMID 20062796, Free PMC Article
  4. Molecular basis for galactosylation of core fucose residues in invertebrates: identification of caenorhabditis elegans N-glycan core alpha1,6-fucoside beta1,4-galactosyltransferase GALT-1 as a member of a novel glycosyltransferase family. Titz A, et al. J Biol Chem, 2009 Dec 25. PMID 19858195, Free PMC Article
  5. Isolation and molecular identification of nematode surface mutants with resistance to bacterial pathogens. O'Rourke D, et al. G3 (Bethesda), 2023 May 2. PMID 36911920, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables UDP-galactosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glycosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in N-glycan processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein galactosylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular organelle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Beta-1,4-galactosyltransferase galt-1
NP_504545.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    5930905..5933435
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_072144.8 → NP_504545.2  Beta-1,4-galactosyltransferase galt-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_504545.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G4RVA7, O16374
    Conserved Domains (1) summary
    cl11394
    Location:188 → 393
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O16374.4

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