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algn-14 UDP-N-acetylglucosamine transferase subunit ALG14 [ Caenorhabditis elegans ]

Gene ID: 187398, updated on 9-Dec-2024

Summary

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Official Symbol
algn-14
Official Full Name
UDP-N-acetylglucosamine transferase subunit ALG14
Primary source
WormBase:WBGene00019725
Locus tag
CELE_M02B7.4
See related
AllianceGenome:WB:WBGene00019725
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable transferase activity. Predicted to be involved in dolichol-linked oligosaccharide biosynthetic process. Predicted to be located in nuclear membrane. Predicted to be part of UDP-N-acetylglucosamine transferase complex. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 15. Orthologous to human ALG14 (ALG14 UDP-N-acetylglucosaminyltransferase subunit). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See algn-14 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
4
Sequence:
Chromosome: IV; NC_003282.8 (3800872..3803426, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase Neighboring gene ncRNA Neighboring gene ShKT domain-containing protein Neighboring gene Osmotic avoidance abnormal protein 3 Neighboring gene Exonuclease domain-containing protein Neighboring gene ncRNA Neighboring gene FTH domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. U12 type introns were lost at multiple occasions during evolution. Bartschat S, et al. BMC Genomics, 2010 Feb 11. PMID 20149226, Free PMC Article
  2. RNAi screening of human glycogene orthologs in the nematode Caenorhabditis elegans and the construction of the C. elegans glycogene database. Akiyoshi S, et al. Glycobiology, 2015 Jan. PMID 25091817, Free PMC Article
  3. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in dolichol-linked oligosaccharide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dolichol-linked oligosaccharide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of UDP-N-acetylglucosamine transferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
UDP-N-acetylglucosamine transferase subunit ALG14
NP_001294286.1
  • Confirmed by transcript evidence
NP_001294287.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    3800872..3803426 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001307357.2 → NP_001294286.1  UDP-N-acetylglucosamine transferase subunit ALG14 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294286.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PQW2
    Conserved Domains (1) summary
    pfam08660
    Location:45 → 213
    Alg14; Oligosaccharide biosynthesis protein Alg14 like

  2. NM_001307358.3 → NP_001294287.1  UDP-N-acetylglucosamine transferase subunit ALG14 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294287.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PE03
    Conserved Domains (1) summary
    pfam08660
    Location:45 → 227
    Alg14; Oligosaccharide biosynthesis protein Alg14 like
Nucleotide Protein
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