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lge-1 Glycosyltransferase-like protein LARGE [ Caenorhabditis elegans ]

Gene ID: 187206, updated on 2-Nov-2024

Summary

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Official Symbol
lge-1
Official Full Name
Glycosyltransferase-like protein LARGE
Primary source
WormBase:WBGene00010716
Locus tag
CELE_K09C8.4
See related
AllianceGenome:WB:WBGene00010716
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable glucuronosyltransferase activity and xylosyltransferase activity. Predicted to be involved in protein O-linked mannosylation. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Human ortholog(s) of this gene implicated in congenital muscular dystrophy-dystroglycanopathy type A6 and muscular dystrophy-dystroglycanopathy type B6. Orthologous to several human genes including LARGE2 (LARGE xylosyl- and glucuronyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See lge-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
11
Sequence:
Chromosome: X; NC_003284.9 (10966551..10969901)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Transmembrane protein Neighboring gene Zinc metalloproteinase nas-10 Neighboring gene ncRNA Neighboring gene tRNA-Gly Neighboring gene Secreted protein Neighboring gene Uncharacterized protein Neighboring gene Peroxidasin homolog pxn-2 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  2. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables glucuronosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables xylosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein O-linked mannosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Glycosyltransferase-like protein LARGE
NP_509833.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    10966551..10969901
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077432.6 → NP_509833.3  Glycosyltransferase-like protein LARGE [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509833.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q21389
    Conserved Domains (3) summary
    cd06431
    Location:42 → 317
    GT8_LARGE_C; LARGE catalytic domain has closest homology to GT8 glycosyltransferase involved in lipooligosaccharide synthesis
    COG1442
    Location:62 → 288
    RfaJ; Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis]
    pfam13896
    Location:354 → 603
    Glyco_transf_49; Glycosyl-transferase for dystroglycan
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q21389.3

Gene LinkOut

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