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rpi-2 Protein XRP2 [ Caenorhabditis elegans ]

Gene ID: 187156, updated on 2-Nov-2024

Summary

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Official Symbol
rpi-2
Official Full Name
Protein XRP2
Primary source
WormBase:WBGene00019536
Locus tag
CELE_K08D12.2
See related
AllianceGenome:WB:WBGene00019536
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable GTPase activator activity. Involved in protein localization to non-motile cilium. Located in cilium and periciliary membrane compartment. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 2. Orthologous to human RP2 (RP2 activator of ARL3 GTPase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rpi-2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
6
Sequence:
Chromosome: IV; NC_003282.8 (1711262..1714897)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Proteasome subunit beta Neighboring gene CCHC-type domain-containing protein;CCHC-type zinc finger nucleic acid binding protein Neighboring gene Ascaris suum EPICuticlin protein related Neighboring gene Ascaris suum EPICuticlin protein related

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mistrafficking of prenylated proteins causes retinitis pigmentosa 2. Zhang H, et al. FASEB J, 2015 Mar. PMID 25422369, Free PMC Article
  2. WDR31 displays functional redundancy with GTPase-activating proteins (GAPs) ELMOD and RP2 in regulating IFT complex and recruiting the BBSome to cilium. Cevik S, et al. Life Sci Alliance, 2023 Aug. PMID 37208194, Free PMC Article
  3. Ift88, but not Kif3a, is required for establishment of the periciliary membrane compartment. Kotsis F, et al. Biochem Biophys Res Commun, 2021 Dec 20. PMID 34753064
  4. CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function. Canning P, et al. Cell Rep, 2018 Jan 23. PMID 29420175, Free PMC Article
  5. A gene-centered C. elegans protein-DNA interaction network provides a framework for functional predictions. Fuxman Bass JI, et al. Mol Syst Biol, 2016 Oct 24. PMID 27777270, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in post-Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to non-motile cilium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cilium IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in periciliary membrane compartment IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in periciliary membrane compartment IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Protein XRP2
NP_500127.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    1711262..1714897
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067726.3 → NP_500127.2  Protein XRP2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500127.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q966I6
    Conserved Domains (1) summary
    pfam07986
    Location:69 → 187
    TBCC; Tubulin binding cofactor C
Nucleotide Protein
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