xpa-1 XPA C-terminal domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: xpa-1
Official Full Name: XPA C-terminal domain-containing protein
Primary source: WormBase:WBGene00006963
Locus tag: CELE_K07G5.2
See related: AllianceGenome:WB:WBGene00006963
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable damaged DNA binding activity. Involved in several processes, including DNA repair; determination of adult lifespan; and response to UV-C. Located in nucleus. Human ortholog(s) of this gene implicated in xeroderma pigmentosum and xeroderma pigmentosum group A. Orthologous to human XPA (XPA, DNA damage recognition and repair factor). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See xpa-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 5

Sequence:: Chromosome: I; NC_003279.8 (7159714..7160917)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of NTH-1, the only Base Excision Repair enzyme known to initiate repair of oxidative DNA damage in C. elegans, restores normal lifespan of the short-lived Nucleotide Excision Repair deficient xpa-1 mutant.
Title: A two-tiered compensatory response to loss of DNA repair modulates aging and stress response pathways.
C. elegans carrying a mutation in xpa-1/rad-3 are hypersensitive and hypermutable in response to UV irradiation, but not to oxidative stress.
Title: Nucleotide excision repair and the degradation of RNA pol II by the Caenorhabditis elegans XPA and Rsp5 orthologues, RAD-3 and WWP-1.
Ce-XPA is involved in the repair of UV-damaged DNA in C. elegans
Title: The Caenorhabditis elegans XPA homolog of human XPA.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K07G5.2 (e-PCR)
- UniSTS:306423

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables damaged DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables damaged DNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in DNA damage response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in UV-damage excision repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in UV-damage excision repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in base-excision repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in base-excision repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleotide-excision repair	IEA Inferred from Electronic Annotation more info
involved_in nucleotide-excision repair	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nucleotide-excision repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleotide-excision repair involved in interstrand cross-link repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleotide-excision repair, DNA damage recognition	IBA Inferred from Biological aspect of Ancestor more info
involved_in reproductive process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to UV	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to UV	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to UV-C	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vulval development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of nucleotide-excision repair factor 1 complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: XPA C-terminal domain-containing protein

NP_492025.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

7159714..7160917

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059624.2 → NP_492025.1 XPA C-terminal domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492025.1

Status: REVIEWED

UniProtKB/TrEMBL

Q21302

Conserved Domains (1) summary

TIGR00598
Location:71 → 241

rad14; DNA repair protein