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mlc-6 EF-hand domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 186979, updated on 4-Jan-2025

Summary

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Official Symbol
mlc-6
Official Full Name
EF-hand domain-containing protein
Primary source
WormBase:WBGene00010554
Locus tag
CELE_K04C1.4
See related
AllianceGenome:WB:WBGene00010554
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable calcium ion binding activity. Predicted to be part of myosin II complex. Human ortholog(s) of this gene implicated in cardiomyopathy and familial atrial fibrillation. Orthologous to human MYL4 (myosin light chain 4); MYL6 (myosin light chain 6); and MYL6B (myosin light chain 6B). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See mlc-6 in Genome Data Viewer
Location:
chromosome: X
Exon count:
4
Sequence:
Chromosome: X; NC_003284.9 (14245591..14246618, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene SAM domain-containing protein Neighboring gene Fork-head domain-containing protein Neighboring gene non-specific serine/threonine protein kinase Neighboring gene non-specific serine/threonine protein kinase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evidence of glutathione transferase complexing and signaling in the model nematode Caenorhabditis elegans using a pull-down proteomic assay. Greetham D, et al. Proteomics, 2004 Jul. PMID 15221760
  2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of myosin II complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
EF-hand domain-containing protein
NP_510375.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    14245591..14246618 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077974.5 → NP_510375.2  EF-hand domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510375.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q21201
    Conserved Domains (3) summary
    PTZ00184
    Location:5 → 143
    PTZ00184; calmodulin; Provisional
    cd00051
    Location:9 → 65
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl08302
    Location:82 → 142
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
Nucleotide Protein
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