exp-1 Gamma-aminobutyric acid receptor exp-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: exp-1
Official Full Name: Gamma-aminobutyric acid receptor exp-1
Primary source: WormBase:WBGene00001373
Locus tag: CELE_H35N03.1
See related: AllianceGenome:WB:WBGene00001373
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables GABA receptor activity and excitatory extracellular ligand-gated monoatomic ion channel activity. Involved in several processes, including lipid transport involved in lipid storage; metal ion transport; and positive regulation of intestinal lipid absorption. Located in neuromuscular junction. Is expressed in Y cell; enteric muscle; and neurons. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See exp-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 16

Sequence:: Chromosome: II; NC_003280.10 (6157144..6161094, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We show that aggregation and bordering are genetically complex, with multiple contributing quantitative trait loci (QTLs), and refine one QTL to identify a new gene affecting the daf-7 pathway, the GABA receptor EXP-1.
Title: Long-range regulatory polymorphisms affecting a GABA receptor constitute a quantitative trait locus (QTL) for social behavior in Caenorhabditis elegans.
This experiment show that GABA mediates enteric muscle contraction in the nematode Caenorhabditis elegans via the EXP-1 receptor, a cation-selective ligand-gated ion channel.
Title: EXP-1 is an excitatory GABA-gated cation channel.
The intracellular region of EXP-1, an excitatory GABA receptor, specifically binds to calcineurin A; calcineurin functions as a negative regulator of excitatory GABA receptor in GABA signaling in C.elegans
Title: Calcineurin regulates enteric muscle contraction through EXP-1, excitatory GABA-gated channel, in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

H35N03.1 (e-PCR)
- UniSTS:306956

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GABA receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables GABA-A receptor activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables excitatory extracellular ligand-gated monoatomic ion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables extracellular ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in defecation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in lipid transport involved in lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of intestinal lipid absorption	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in sodium ion transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of GABA-A receptor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Gamma-aminobutyric acid receptor exp-1

NP_495229.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

6157144..6161094 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_062828.6 → NP_495229.3 Gamma-aminobutyric acid receptor exp-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495229.3

Status: REVIEWED

UniProtKB/Swiss-Prot

G5ECJ0, Q6TXQ9

Conserved Domains (3) summary

TIGR00860
Location:103 → 515

LIC; Cation transporter family protein

pfam02931
Location:111 → 311

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:320 → 397

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region